Edward Roberts
Overview
Explore the profile of Edward Roberts including associated specialties, affiliations and a list of published articles.
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Articles
53
Citations
1371
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0
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Recent Articles
1.
Rosen H, Roberts E
Adv Pharmacol
. 2024 Nov;
101:183-202.
PMID: 39521600
Sphingosine-1 phosphate (S1P) modulators have received recent FDA-approval for the treatment of moderate-to-severe ulcerative colitis, including agents ozanimod, approved in 2021, and etrasimod, approved in 2023. These oral drugs are...
2.
Hewitt R, Puttur F, Gaboriau D, Fercoq F, Fresquet M, Traves W, et al.
Nat Commun
. 2023 Sep;
14(1):6039.
PMID: 37758700
Aberrant expansion of KRT5 basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity...
3.
Navratilova E, Qu C, Ji G, Neugebauer V, Guerrero M, Rosen H, et al.
Anesthesiology
. 2023 Sep;
140(2):272-283.
PMID: 37725756
Background: The efficiency of descending pain modulation, commonly assessed with the conditioned pain modulation procedure, is diminished in patients with chronic pain. The authors hypothesized that the efficiency of pain...
4.
Sims A, Burgess Tornaletti L, Jasim S, Pirillo C, Devlin R, Hirst J, et al.
PLoS Biol
. 2023 Feb;
21(2):e3001941.
PMID: 36757937
Interactions between viruses during coinfections can influence viral fitness and population diversity, as seen in the generation of reassortant pandemic influenza A virus (IAV) strains. However, opportunities for interactions between...
5.
Pirillo C, Birch F, Tissot F, Gonzalez Anton S, Haltalli M, Tini V, et al.
Blood Adv
. 2022 Feb;
6(10):3126-3141.
PMID: 35157757
Acute myeloid leukemia (AML) is a blood cancer of the myeloid lineage. Its prognosis remains poor, highlighting the need for new therapeutic and precision medicine approaches. AML symptoms often include...
6.
Page S, Mavrikaki M, Lintz T, Puttick D, Roberts E, Rosen H, et al.
Int J Neuropsychopharmacol
. 2019 Oct;
22(11):735-745.
PMID: 31613314
Background: New treatments for stress-related disorders including depression, anxiety, and substance use disorder are greatly needed. Kappa opioid receptors are expressed in the central nervous system, including areas implicated in...
7.
Guerrero M, Urbano M, Kim E, Gamo A, Riley S, Abgaryan L, et al.
J Med Chem
. 2019 Feb;
62(4):1761-1780.
PMID: 30707578
κ opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists...
8.
Harris R, Bajo M, Bell R, Blednov Y, Varodayan F, Truitt J, et al.
J Neurosci
. 2016 Dec;
37(5):1139-1155.
PMID: 27986929
Significance Statement: Toll-like receptor 4 (TLR4) is a key mediator of innate immune signaling and has been implicated in alcohol responses in animal models and human alcoholics. Members of the...
9.
Burkert K, Zellmann T, Meier R, Kaiser A, Stichel J, Meiler J, et al.
ChemMedChem
. 2016 Nov;
12(1):75-85.
PMID: 27874262
The neuropeptide Y receptor (Y R) is involved in various pathophysiological processes such as epilepsy, mood disorders, angiogenesis, and tumor growth. Therefore, the Y R is an interesting target for...
10.
Guerrero M, Urbano M, Roberts E
Expert Opin Ther Pat
. 2016 Mar;
26(4):455-70.
PMID: 26947494
Introduction: The sphingosine-1-phosphate (S1P) regulates diverse biological functions including cell proliferation, endothelial cell chemotaxis, angiogenesis, immune cell trafficking, mitogenesis, heart rate. The first-in-class S1P1,3-5-R pan-agonist fingolimod (FTY720) was approved by...