Edward Roberts
Overview
Explore the profile of Edward Roberts including associated specialties, affiliations and a list of published articles.
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53
Citations
1371
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Recent Articles
11.
Dillmann C, Ringel C, Ringleb J, Mora J, Olesch C, Fink A, et al.
J Immunol
. 2016 Jan;
196(4):1579-90.
PMID: 26783340
Plasmacytoid dendritic cells (pDCs) produce large amounts of type I IFN in response to TLR7/9 ligands. This conveys antiviral effects, activates other immune cells (NK cells, conventional DCs, B, and...
12.
Schreiber S, Kotz J, Li M, Aube J, Austin C, Reed J, et al.
Cell
. 2015 Jun;
161(6):1252-65.
PMID: 26046436
Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous...
13.
Ducrot V, Askem C, Azam D, Brettschneider D, Brown R, Charles S, et al.
Regul Toxicol Pharmacol
. 2014 Sep;
70(3):605-14.
PMID: 25220624
The OECD test guideline development program has been extended in 2011 to establish a partial life-cycle protocol for assessing the reproductive toxicity of chemicals to several mollusk species, including the...
14.
Rosen H, Sanna M, Gonzalez-Cabrera P, Roberts E
Curr Top Microbiol Immunol
. 2014 Apr;
378:1-21.
PMID: 24728591
The understanding of the role of the sphingosine 1-phosphate signaling system in immunology and host defense has deepened exponentially over the past 12 years since the discovery that lymphocyte egress...
15.
Urbano M, Guerrero M, Rosen H, Roberts E
Bioorg Med Chem Lett
. 2014 Apr;
24(9):2021-32.
PMID: 24690494
The research community has increasingly focused on the development of OPRK antagonists as pharmacotherapies for the treatment of depression, anxiety, addictive disorders and other psychiatric conditions produced or exacerbated by...
16.
Bajo M, Madamba S, Roberto M, Blednov Y, Sagi V, Roberts E, et al.
Brain Behav Immun
. 2014 Mar;
40:191-202.
PMID: 24675033
Excessive ethanol drinking in rodent models may involve activation of the innate immune system, especially toll-like receptor 4 (TLR4) signaling pathways. We used intracellular recording of evoked GABAergic inhibitory postsynaptic...
17.
Mittapalli G, Roberts E
Bioorg Med Chem Lett
. 2013 Dec;
24(2):430-41.
PMID: 24365162
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian brain and exerts a variety of physiological processes in humans via four different receptor subtypes Y1, Y2,...
18.
Guerrero M, Poddutoori R, Urbano M, Peng X, Spicer T, Chase P, et al.
Bioorg Med Chem Lett
. 2013 Oct;
23(23):6346-9.
PMID: 24135724
Potent and selective S1P3 receptor (S1P3-R) agonists may represent important proof-of-principle tools used to clarify the receptor biological function and assess the therapeutic potential of the S1P3-R in cardiovascular, inflammatory...
19.
Urbano M, Guerrero M, Rosen H, Roberts E
Bioorg Med Chem Lett
. 2013 Oct;
23(23):6377-89.
PMID: 24125884
The Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in autoimmune settings. S1P1-R is a validated drug target for multiple sclerosis (MS) for...
20.
Cencetti F, Bernacchioni C, Tonelli F, Roberts E, Donati C, Bruni P
FASEB J
. 2013 Aug;
27(11):4532-46.
PMID: 23913862
In view of its multiple detrimental effects, transforming growth factor β1 (TGFβ1) is recognized as critical negative regulator of skeletal muscle repair. Apoptosis of skeletal muscle precursor cells driven by...