Edward R Sherwood
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Explore the profile of Edward R Sherwood including associated specialties, affiliations and a list of published articles.
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94
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2662
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Recent Articles
1.
Hao D, Caja K, McBride M, Owen A, Bohannon J, Hernandez A, et al.
J Leukoc Biol
. 2024 Dec;
PMID: 39722231
Aging significantly increases the incidence and severity of infections, with individuals aged 65 and above accounting for 65% of sepsis cases. Innate immune training, known as "trained immunity" or "innate...
2.
McBride M, Caja K, Patil T, Owen A, Luan L, Bohannon J, et al.
J Leukoc Biol
. 2024 Oct;
117(2).
PMID: 39351765
Treatment with the toll-like receptor 4 agonist monophosphoryl lipid A conditions innate immunocytes to respond robustly to subsequent infection, a phenotype termed innate immune memory. Our published studies show that...
3.
Bolden M, Davis X, Sherwood E, Bohannon J, Caslin H
bioRxiv
. 2024 Aug;
PMID: 39211192
Different stimuli can induce innate immune memory to improve pathogen defense or worsen cardiometabolic disease. However, it is less clear if the same stimuli can induce both the protective and...
4.
Carr S, Clifton J, Freundlich R, Fowler L, Sherwood E, McEvoy M, et al.
Anesth Analg
. 2024 Feb;
138(3):517-529.
PMID: 38364243
Background: We assessed the association between education-based interventions, the frequency of train-of-four (TOF) monitoring, and postoperative outcomes. Methods: We studied adults undergoing noncardiac surgery from February 1, 2020 through October...
5.
McBride M, Stothers C, Fensterheim B, Caja K, Owen A, Hernandez A, et al.
J Leukoc Biol
. 2023 Oct;
115(2):358-373.
PMID: 37793181
Exposure to pathogen-associated molecular patterns (PAMPs) induces an augmented, broad-spectrum antimicrobial response to subsequent infection, a phenomenon termed innate immune memory. This study examined the effects of treatment with β-glucan,...
6.
Hernandez A, Patil N, Brewer M, Delgado R, Himmel L, Lopez L, et al.
Am J Physiol Renal Physiol
. 2023 Mar;
324(5):F472-F482.
PMID: 36995924
Acute kidney injury (AKI) is common in surgical and critically ill patients. This study examined whether pretreatment with a novel Toll-like receptor 4 agonist attenuated ischemia-reperfusion injury (IRI)-induced AKI (IRI-AKI)....
7.
Owen A, Luan L, Burelbach K, McBride M, Stothers C, Boykin O, et al.
Front Immunol
. 2022 Nov;
13:1044662.
PMID: 36439136
Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon exposure...
8.
Hernandez A, Zhou J, Bohannon J, McBride M, Gibson-Corley K, Patil N, et al.
Shock
. 2022 Aug;
58(4):295-303.
PMID: 36018281
Objectives: Nosocomial pneumonia is a common complication in critically ill patients. The goal of this study was to examine the efficacy of the Toll-like receptor 4 agonist 3-deacyl phosphorylated hexacyl...
9.
Gill P, Ozment T, Lewis N, Sherwood E, Williams D
Front Immunol
. 2022 Jun;
13:872652.
PMID: 35693816
Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more...
10.
Sherwood E, Burelbach K, McBride M, Stothers C, Owen A, Hernandez A, et al.
J Immunol
. 2022 Feb;
208(4):785-792.
PMID: 35115374
Unlike the adaptive immune system, the innate immune system has classically been characterized as being devoid of memory functions. However, recent research shows that innate myeloid and lymphoid cells have...