Tushar K Varma
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Explore the profile of Tushar K Varma including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
366
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Recent Articles
1.
Romero C, Varma T, Hobbs J, Reyes A, Driver B, Sherwood E
Infect Immun
. 2011 Jun;
79(9):3576-87.
PMID: 21646453
Monophosphoryl lipid A (MPLA) is a Toll-like receptor 4 (TLR4) agonist that is currently used as a vaccine adjuvant in humans. In this study, we evaluated the effect of MPLA...
2.
Enoh V, Lin S, Lin C, Toliver-Kinsky T, Murphey E, Varma T, et al.
Shock
. 2007 Apr;
27(5):507-19.
PMID: 17438456
The present study was undertaken to determine whether the mice depleted of alphabeta or gammadelta T cells show resistance to acute polymicrobial sepsis caused by cecal ligation and puncture (CLP)....
3.
Murphey E, Fang G, Varma T, Sherwood E
Shock
. 2007 Feb;
27(3):289-95.
PMID: 17304110
Endotoxin (LPS) tolerance is induced by exposure to sublethal doses of LPS, resulting in a suppressed proinflammatory response and an improved survival rate after challenge with a normally lethal dose...
4.
Huang Z, Pereira C, Toliver-Kinsky T, Murphey E, Varma T, Lin C, et al.
J Burn Care Res
. 2006 Sep;
27(5):682-7.
PMID: 16998401
Transforming growth factor-beta (TGF-beta), a cytokine with anti-inflammatory properties, may contribute to postburn immunosuppression. This study was designed to determine whether neutralizing TGF-beta in burned mice could improve resistance to...
5.
Mathru M, Pollard V, He G, Varma T, Ahmad M, Prough D
Shock
. 2006 May;
25(4):338-43.
PMID: 16670634
This study was performed to determine whether endotoxemia causes diastolic cardiac dysfunction. Eleven healthy volunteers, 30 +/- 6 years of age, underwent comprehensive transthoracic echocardiographic assessment including two-dimensional, M-mode transmitral...
6.
Enoh V, Fairchild C, Lin C, Varma T, Sherwood E
Am J Physiol Regul Integr Comp Physiol
. 2005 Nov;
290(3):R685-93.
PMID: 16269570
CD8 knockout mice depleted of natural killer (NK) cells by treatment with anti-asialoGM1 (CD8KO/alphaAsGM1 mice) are resistant to injury caused by cecal ligation and puncture (CLP). However, CLP-induced injury is...
7.
Varma T, Durham M, Murphey E, Cui W, Huang Z, Lin C, et al.
Infect Immun
. 2005 Oct;
73(11):7340-7.
PMID: 16239532
Endotoxin (lipopolysaccharide [LPS]) tolerance is an altered state of immunity caused by prior exposure to LPS, in which production of many cytokines, including gamma interferon (IFN-gamma) and interleukin-12 (IL-12), are...
8.
Enoh V, Lin C, Varma T, Sherwood E
Am J Physiol Gastrointest Liver Physiol
. 2005 Sep;
290(2):G277-84.
PMID: 16166341
Our previous studies showed that beta(2)-microglobulin knockout mice treated with anti-asialoGM1 (beta2MKO/alphaAsGM1 mice) are resistant to injury caused by cecal ligation and puncture (CLP). However, CLP-induced injury is complex. Potential...
9.
Saito H, Sherwood E, Varma T, Evers B
Mech Ageing Dev
. 2003 Dec;
124(10-12):1047-58.
PMID: 14659593
Aging is accompanied by an altered stress response that underlies increased susceptibility of the elderly patients to physiological stress such as infection and sepsis. In the present study, we investigated...
10.
Mathura V, Soman K, Varma T, Braun W
J Mol Model
. 2003 Oct;
9(5):298-303.
PMID: 14517609
A monomeric model for murine antiapoptotic protein Bcl-2 was constructed by comparative modeling with the software suite MPACK (EXDIS/DIAMOD/FANTOM) using human Bcl-xL as a template. The monomeric model shows that...