Edward K Gilding
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Explore the profile of Edward K Gilding including associated specialties, affiliations and a list of published articles.
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32
Citations
603
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Recent Articles
1.
Gilding E, Jackson M, Nguyen L, Hamilton B, Farquharson K, Ho W, et al.
Nat Commun
. 2024 Aug;
15(1):6565.
PMID: 39095373
The legume albumin-1 gene family, arising after nodulation, encodes linear a- and b-chain peptides for nutrient storage and defense. Intriguingly, in one prominent legume, Clitoria ternatea, the b-chains are replaced...
2.
Khatibi N, Huang Y, Wang C, Durek T, Gilding E, Craik D
J Nat Prod
. 2024 May;
88(1):24-35.
PMID: 38747744
Cyclotides are cysteine-rich plant-derived peptides composed of 28-37 amino acids with a head-to-tail cyclic backbone and a knotted arrangement of three conserved disulfide bonds. Their beneficial biophysical properties make them...
3.
Bajpai A, Jackson M, Huang Y, Yap K, Du Q, Chau T, et al.
J Nat Prod
. 2023 Apr;
86(5):1222-1229.
PMID: 37099442
Cyclotides are a unique family of stable and cyclic mini-proteins found in plants that have nematicidal and anthelmintic activities. They are distributed across the Rubiaceae, Violaceae, Fabaceae, Cucurbitaceae, and Solanaceae...
4.
Jackson M, Xie J, Nguyen L, Wang X, Yap K, Harvey P, et al.
Transgenic Res
. 2023 Mar;
32(1-2):121-133.
PMID: 36930229
Multiple sclerosis (MS) is a debilitating disease that requires prolonged treatment with often severe side effects. One experimental MS therapeutic currently under development is a single amino acid mutant of...
5.
Dang T, Huang Y, Ott S, Harvey P, Gilding E, Tombling B, et al.
J Biol Chem
. 2022 Aug;
298(10):102413.
PMID: 36007611
Cyclotides and acyclic versions of cyclotides (acyclotides) are peptides involved in plant defense. These peptides contain a cystine knot motif formed by three interlocked disulfide bonds, with the main difference...
6.
Xie J, Robinson S, Gilding E, Jami S, Deuis J, Rehm F, et al.
J Biol Chem
. 2022 Jul;
298(8):102218.
PMID: 35780839
The stinging hairs of plants from the family Urticaceae inject compounds that inflict pain to deter herbivores. The sting of the New Zealand tree nettle (Urtica ferox) is among the...
7.
Rational domestication of a plant-based recombinant expression system expands its biosynthetic range
Jackson M, Chan L, Harding M, Craik D, Gilding E
J Exp Bot
. 2022 Jun;
73(18):6103-6114.
PMID: 35724659
Plant molecular farming aims to provide a green, flexible, and rapid alternative to conventional recombinant expression systems, capable of producing complex biologics such as enzymes, vaccines, and antibodies. Historically, the...
8.
Doffek B, Huang Y, Huang Y, Chan L, Gilding E, Jackson M, et al.
Phytochemistry
. 2021 Dec;
195:113053.
PMID: 34923360
Cyclotides are a class of ribosomally-synthesized plant peptides that function in plants as a defense against insects and fungal pathogens. Their unique structure comprises a cyclized peptide backbone threaded by...
9.
Dang T, Chan L, Tombling B, Harvey P, Gilding E, Craik D
J Nat Prod
. 2021 Feb;
84(2):395-407.
PMID: 33570395
Cyclotides are plant-derived peptides that have attracted interest as biocides and scaffolds for the development of stable peptide therapeutics. Cyclotides are characterized by their cyclic backbone and cystine knot framework,...
10.
Tombling B, Lammi C, Lawrence N, Gilding E, Grazioso G, Craik D, et al.
J Med Chem
. 2020 Dec;
64(5):2523-2533.
PMID: 33356222
Peptides are regarded as promising next-generation therapeutics. However, an analysis of over 1000 bioactive peptide candidates suggests that many have underdeveloped affinities and could benefit from cyclization using a bridging...