Edward H Leiter
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Explore the profile of Edward H Leiter including associated specialties, affiliations and a list of published articles.
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59
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1575
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Recent Articles
1.
Chen J, Li R, Knapp S, Zhu G, Whitener R, Leiter E, et al.
Front Genet
. 2022 Oct;
13:994501.
PMID: 36276935
Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice...
2.
Singh B, Krawetz M, De Lima R, Mukherjee R, Chaturvedi P, Lee-Chan E, et al.
Arch Immunol Ther Exp (Warsz)
. 2017 Jul;
66(1):11-19.
PMID: 28733878
Transforming growth factor (TGF)-β has been implicated in regulation of the immune system, including autoimmunity. We have found that TGF-β is readily produced by T cells following immunization with self-peptide...
3.
Presa M, Chen Y, Grier A, Leiter E, Brehm M, Greiner D, et al.
J Immunol
. 2015 Aug;
195(7):3011-9.
PMID: 26283479
NOD-scid.Il2rg(null) (NSG) mice are currently being used as recipients to screen for pathogenic autoreactive T cells in type 1 diabetes (T1D) patients. We questioned whether the restriction of IL-2R γ-chain...
4.
Simecek P, Churchill G, Yang H, Rowe L, Herberg L, Serreze D, et al.
G3 (Bethesda)
. 2015 Mar;
5(5):771-5.
PMID: 25740934
The non-obese diabetic (NOD) mouse is a polygenic model for type 1 diabetes that is characterized by insulitis, a leukocytic infiltration of the pancreatic islets. During ~35 years since the...
5.
Leiter E, Schile A
Curr Protoc Mouse Biol
. 2014 Mar;
3(1):9-19.
PMID: 24592352
Type 1 diabetes (T1D) is characterized by a partial or total insufficiency of insulin. The premiere animal model of autoimmune T cell-mediated T1D is the NOD mouse. A dominant negative...
6.
Leiter E, Strobel M, ONeill A, Schultz D, Schile A, Reifsnyder P
J Diabetes Res
. 2013 May;
2013:165327.
PMID: 23671854
This review compares two novel polygenic mouse models of type 2 diabetes (T2D), TALLYHO/JngJ and NONcNZO10/LtJ, and contrasts both with the well-known C57BLKS/J-Lepr(db) (db/db) monogenic diabesity model. We posit that...
7.
Chen Y, Scheuplein F, Driver J, Hewes A, Reifsnyder P, Leiter E, et al.
J Immunol
. 2011 Mar;
186(7):4278-84.
PMID: 21357538
Although P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined. To test this possibility, we...
8.
Chen J, Gusdon A, Piganelli J, Leiter E, Mathews C
Diabetes
. 2010 Oct;
60(1):355-9.
PMID: 20980458
Objective: To investigate whether a single nucleotide polymorphism (SNP) in the mitochondrial gene for NADH dehydrogenase 2 (mt-Nd2) can modulate susceptibility to type 1 diabetes in NOD mice. Research Design...
9.
Nicholson A, Reifsnyder P, Malcolm R, Lucas C, MacGregor G, Zhang W, et al.
Obesity (Silver Spring)
. 2010 Jan;
18(10):1902-5.
PMID: 20057372
The C57BL/6J (B6/J) male mouse represents a standard for diet-induced obesity (DIO) and is unique in expressing a loss-of-function nicotinamide nucleotide transhydrogenase (Nnt) gene. This mutation was associated with a...
10.
Bleich A, Buchler G, Beckwith J, Petell L, Affourtit J, King B, et al.
Inflamm Bowel Dis
. 2009 Oct;
16(5):765-75.
PMID: 19856416
Background: The cytokine-deficiency-induced colitis susceptibility (Cdcs)1 locus is a major modifier of murine inflammatory bowel disease (IBD) and was originally identified in experimental crosses of interleukin-10-deficient (Il10(-/-)) mice. Congenic mice,...