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Clayton E Mathews

Explore the profile of Clayton E Mathews including associated specialties, affiliations and a list of published articles. Areas
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Articles 124
Citations 3139
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Recent Articles
1.
Huber M, Widener A, Cuaycal A, Smurlick D, Butterworth E, Lenchik N, et al.
bioRxiv . 2025 Jan; PMID: 39763971
The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. Yet, at onset of T1D, patients often have a...
2.
Barrios E, Balzano-Nogueira L, Polcz V, Rodhouse C, Leary J, Darden D, et al.
Front Immunol . 2024 Dec; 15:1478471. PMID: 39691721
Introduction: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is...
3.
Brown M, Thirawatananond P, Peters L, Kern E, Vijay S, Sachs L, et al.
Diabetologia . 2024 Dec; 68(2):397-418. PMID: 39636437
Aims/hypothesis: Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset in type 1 diabetes. There is an outstanding need to augment the durability and...
4.
Swensen A, Piehowski P, Chen J, Chan X, Kelly S, Petyuk V, et al.
bioRxiv . 2024 Sep; PMID: 39345556
Aims/hypothesis: Progression to type 1 diabetes (T1D) is associated with genetic factors, the presence of autoantibodies, and a decline in β cell insulin secretion in response to glucose. Very little...
5.
Kwon Y, Woo J, Yu F, Williams S, Markillie L, Moore R, et al.
Mol Cell Proteomics . 2024 Sep; 23(11):100841. PMID: 39307423
Multiplexed bimolecular profiling of tissue microenvironment, or spatial omics, can provide deep insight into cellular compositions and interactions in healthy and diseased tissues. Proteome-scale tissue mapping, which aims to unbiasedly...
6.
Brown M, Thirawatananond P, Peters L, Kern E, Vijay S, Sachs L, et al.
bioRxiv . 2024 Jul; PMID: 39071293
Aims/hypothesis: Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset in type 1 diabetes. A growing number of T cell-directed therapeutics have demonstrated partial...
7.
Barrios E, Leary J, Darden D, Rincon J, Willis M, Polcz V, et al.
Front Immunol . 2024 May; 15:1355405. PMID: 38720891
Introduction: Sepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist...
8.
Barrios E, Rincon J, Willis M, Polcz V, Leary J, Darden D, et al.
Shock . 2024 May; 62(2):208-216. PMID: 38713581
Postsepsis early mortality is being replaced by survivors who experience either a rapid recovery and favorable hospital discharge or the development of chronic critical illness with suboptimal outcomes. The underlying...
9.
Sylvester-Armstrong K, Reeder C, Powell A, Becker M, Hagan D, Chen J, et al.
Islets . 2024 Mar; 16(1):2334044. PMID: 38533763
Pancreatic beta cells are among the slowest replicating cells in the human body and have not been observed to increase in number except during the fetal and neonatal period, in...
10.
Kwon Y, Woo J, Yu F, Williams S, Markillie L, Moore R, et al.
bioRxiv . 2024 Mar; PMID: 38496682
Multiplexed bimolecular profiling of tissue microenvironment, or spatial omics, can provide deep insight into cellular compositions and interactions in healthy and diseased tissues. Proteome-scale tissue mapping, which aims to unbiasedly...