Edward F Srour
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Explore the profile of Edward F Srour including associated specialties, affiliations and a list of published articles.
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92
Citations
2914
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Recent Articles
21.
Anjanappa M, Cardoso A, Cheng L, Mohamad S, Gunawan A, Rice S, et al.
Cancer Res
. 2017 Mar;
77(10):2759-2769.
PMID: 28249895
There is a need to individualize assays for tumor molecular phenotyping, given variations in the differentiation status of tumor and normal tissues in different patients. To address this, we performed...
22.
Hinge A, Xu J, Javier J, Mose E, Kumar S, Kapur R, et al.
Nat Commun
. 2017 Feb;
8:14382.
PMID: 28176763
The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices remain ill-defined. Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-β-p38 balances HSPC self-renewal and differentiation. Upon transplantation,...
23.
Olivos 3rd D, Alvarez M, Cheng Y, Hooker R, Ciovacco W, Bethel M, et al.
J Cell Biochem
. 2017 Jan;
118(8):2231-2240.
PMID: 28067429
The Lnk adapter protein negatively regulates the signaling of thrombopoietin (TPO), the main megakaryocyte (MK) growth factor. Lnk-deficient (-/-) mice have increased TPO signaling and increased MK number. Interestingly, several...
24.
Cell Adhesion Molecule CD166 Drives Malignant Progression and Osteolytic Disease in Multiple Myeloma
Xu L, Mohammad K, Wu H, Crean C, Poteat B, Cheng Y, et al.
Cancer Res
. 2016 Sep;
76(23):6901-6910.
PMID: 27634757
Multiple myeloma is incurable once osteolytic lesions have seeded at skeletal sites, but factors mediating this deadly pathogenic advance remain poorly understood. Here, we report evidence of a major role...
25.
Silberstein L, Goncalves K, Kharchenko P, Turcotte R, Kfoury Y, Mercier F, et al.
Cell Stem Cell
. 2016 Aug;
19(4):530-543.
PMID: 27524439
Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on the differential single-cell gene expression analysis of...
26.
Meijome T, Ekwealor J, Hooker R, Cheng Y, Ciovacco W, Balamohan S, et al.
J Cell Biochem
. 2015 Sep;
117(4):959-69.
PMID: 26375403
C-Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c-Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been...
27.
Chitteti B, Kacena M, Voytik-Harbin S, Srour E
J Immunol Methods
. 2015 Jul;
425:108-113.
PMID: 26159389
To recreate the in vivo hematopoietic cell microenvironment or niche and to study the impact of extracellular matrix (ECM) biophysical properties on hematopoietic progenitor cell (HPC) proliferation and function, mouse...
28.
Mantel C, OLeary H, Chitteti B, Huang X, Cooper S, Hangoc G, et al.
Cell
. 2015 Jun;
161(7):1553-65.
PMID: 26073944
Hematopoietic stem cells (HSCs) reside in hypoxic niches within bone marrow and cord blood. Yet, essentially all HSC studies have been performed with cells isolated and processed in non-physiologic ambient...
29.
Capitano M, Chitteti B, Cooper S, Srour E, Bartke A, Broxmeyer H
Blood Cells Mol Dis
. 2015 May;
55(1):15-20.
PMID: 25976461
Ames hypopituitary dwarf mice are deficient in growth hormone, thyroid-stimulating hormone, and prolactin. The phenotype of these mice demonstrates irregularities in the immune system with skewing of the normal cytokine...
30.
Wang L, Zoetemelk M, Chitteti B, Ratliff T, Myers J, Srour E, et al.
Am J Physiol Renal Physiol
. 2015 May;
308(12):F1421-30.
PMID: 25925259
Prostatic inflammation is a nearly ubiquitous pathological feature observed in specimens from benign prostate hyperplasia and prostate cancer patients. The microenvironment of the inflamed prostate is highly reactive, and epithelial...