Christie M Orschell
Overview
Explore the profile of Christie M Orschell including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1900
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Recent Articles
1.
Wesolowski R, Fish B, Eibl M, Bahr S, Munjal Mehta S, Czajkowski M, et al.
Int J Radiat Biol
. 2024 Nov;
101(1):1-14.
PMID: 39531584
Repurposing therapeutic agents with existing clinical data is a common strategy for developing radiation countermeasures. IEPA (imidazolyl ethanamide pentandioic acid) is an orally bioavailable small molecule pseudopeptide with myeloprotective properties,...
2.
Plett P, Chua H, Wu T, Sampson C, Guise T, Wright L, et al.
Radiat Res
. 2024 Aug;
202(3):580-598.
PMID: 39099001
Acute, high-dose radiation exposure results in life-threatening acute radiation syndrome (ARS) and debilitating delayed effects of acute radiation exposure (DEARE). The DEARE are a set of chronic multi-organ illnesses that...
3.
Langevin B, Singh P, Plett P, Sampson C, Masters A, Gibbs A, et al.
Radiat Res
. 2023 Nov;
201(1):7-18.
PMID: 38019093
Exposure to high-dose ionizing radiation can lead to life-threatening injuries and mortality. Bone marrow is the most sensitive organ to radiation damage, resulting in the hematopoietic acute radiation syndrome (H-ARS)...
4.
Wu T, Pelus L, Plett P, Sampson C, Chua H, Fisher A, et al.
Radiat Res
. 2023 Apr;
199(5):468-489.
PMID: 37014943
Survivors of acute radiation exposure suffer from the delayed effects of acute radiation exposure (DEARE), a chronic condition affecting multiple organs, including lung, kidney, heart, gastrointestinal tract, eyes, and brain,...
5.
Wu T, Orschell C
Int J Radiat Biol
. 2023 Mar;
99(7):1066-1079.
PMID: 36862990
Purpose: Terrorist use of nuclear weapons and radiation accidents put the human population at risk for exposure to life-threatening levels of radiation. Victims of lethal radiation exposure face potentially lethal...
6.
Orschell C, Wu T, Patterson A
Curr Stem Cell Rep
. 2023 Feb;
8(3):139-149.
PMID: 36798890
Purpose Of Review: Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Radiation medical countermeasure (MCM)...
7.
Kernagis D, Balcer-Kubiczek E, Bazyar S, Orschell C, Jackson I
Life Sci Space Res (Amst)
. 2022 Nov;
35:36-43.
PMID: 36336367
More than 50 years after the Apollo missions ended, the National Aeronautical and Space Administration (NASA) and other international space agencies are preparing a return to the moon as a...
8.
Plett P, Pelus L, Orschell C
Methods Mol Biol
. 2022 Oct;
2567:251-262.
PMID: 36255706
The hematopoietic system is one of the most sensitive tissues to ionizing radiation, and radiation doses from 2 to 10 gray can result in death from bleeding and infection if...
9.
Patterson A, Orschell C, Pelus L
Methods Mol Biol
. 2022 Oct;
2567:127-140.
PMID: 36255699
Radiation exposure is particularly damaging to cells of the hematopoietic system, inducing pancytopenia and bone marrow failure. The study of these processes, as well as the development of treatments to...
10.
Patterson A, Vemula S, Plett P, Sampson C, Chua H, Fisher A, et al.
Radiat Res
. 2022 Jul;
198(3):221-242.
PMID: 35834823
The hematopoietic system is highly sensitive to stress from both aging and radiation exposure, and the hematopoietic acute radiation syndrome (H-ARS) should be modeled in the geriatric context separately from...