Edward Baidoo
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Explore the profile of Edward Baidoo including associated specialties, affiliations and a list of published articles.
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13
Citations
541
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Recent Articles
1.
Eng T, Banerjee D, Menasalvas J, Chen Y, Gin J, Choudhary H, et al.
Cell Rep
. 2023 Sep;
42(9):113087.
PMID: 37665664
Maximizing the production of heterologous biomolecules is a complex problem that can be addressed with a systems-level understanding of cellular metabolism and regulation. Specifically, growth-coupling approaches can increase product titers...
2.
Zhang J, Hansen L, Gudich O, Viehrig K, Lassen L, Schrubbers L, et al.
Nature
. 2022 Aug;
609(7926):341-347.
PMID: 36045295
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine. As MIAs are difficult to...
3.
Jing B, Ishikawa T, Soltis N, Inada N, Liang Y, Murawska G, et al.
Plant Direct
. 2021 Mar;
5(3):e00309.
PMID: 33763627
Glycosylinositolphosphorylceramides (GIPCs) are the predominant lipid in the outer leaflet of the plasma membrane. Characterized GIPC glycosylation mutants have severe or lethal plant phenotypes. However, the function of the glycosylation...
4.
Yaegashi J, Kirby J, Ito M, Sun J, Dutta T, Mirsiaghi M, et al.
Biotechnol Biofuels
. 2017 Oct;
10:241.
PMID: 29075325
Background: Economical conversion of lignocellulosic biomass into biofuels and bioproducts is central to the establishment of a robust bioeconomy. This requires a conversion host that is able to both efficiently...
5.
Tartaglio V, Rennie E, Cahoon R, Wang G, Baidoo E, Mortimer J, et al.
Plant J
. 2016 Sep;
89(2):278-290.
PMID: 27643972
Sphingolipids are a major component of plant plasma membranes and endomembranes, and mediate a diverse range of biological processes. Study of the highly glycosylated glycosyl inositol phosphorylceramide (GIPC) sphingolipids has...
6.
Brunk E, George K, Alonso-Gutierrez J, Thompson M, Baidoo E, Wang G, et al.
Cell Syst
. 2016 May;
2(5):335-46.
PMID: 27211860
Understanding the complex interactions that occur between heterologous and native biochemical pathways represents a major challenge in metabolic engineering and synthetic biology. We present a workflow that integrates metabolomics, proteomics, ...
7.
Kang A, George K, Wang G, Baidoo E, Keasling J, Lee T
Metab Eng
. 2015 Dec;
34:25-35.
PMID: 26708516
Branched C5 alcohols are promising biofuels with favorable combustion properties. A mevalonate (MVA)-based isoprenoid biosynthetic pathway for C5 alcohols was constructed in Escherichia coli using genes from several organisms, and...
8.
George K, Thompson M, Kang A, Baidoo E, Wang G, Chan L, et al.
Sci Rep
. 2015 Jun;
5:11128.
PMID: 26052683
Branched five carbon (C5) alcohols are attractive targets for microbial production due to their desirable fuel properties and importance as platform chemicals. In this study, we engineered a heterologous isoprenoid...
9.
Weaver L, Sousa M, Wang G, Baidoo E, Petzold C, Keasling J
Biotechnol Bioeng
. 2014 Jul;
112(1):111-9.
PMID: 24981116
To aid in debugging efforts to increase yield, titer, and productivity of engineered metabolic pathways, computational models are increasingly needed to predict how changes in experimentally manipulable variables such as...
10.
Dahl R, Zhang F, Alonso-Gutierrez J, Baidoo E, Batth T, Redding-Johanson A, et al.
Nat Biotechnol
. 2013 Oct;
31(11):1039-46.
PMID: 24142050
Heterologous pathways used in metabolic engineering may produce intermediates toxic to the cell. Dynamic control of pathway enzymes could prevent the accumulation of these metabolites, but such a strategy requires...