Eduardo Seclen
Overview
Explore the profile of Eduardo Seclen including associated specialties, affiliations and a list of published articles.
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19
Citations
336
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0
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Recent Articles
1.
Moiani A, Letort G, Lizot S, Chalumeau A, Foray C, Felix T, et al.
Nat Commun
. 2024 Jun;
15(1):4965.
PMID: 38862518
Sickle cell disease is a devastating blood disorder that originates from a single point mutation in the HBB gene coding for hemoglobin. Here, we develop a GMP-compatible TALEN-mediated gene editing...
2.
Seclen E, Jang J, Lawal A, Pulicani S, Boyne A, Tkach D, et al.
Mol Ther
. 2024 Apr;
32(6):1643-1657.
PMID: 38582963
Gene therapy in hematopoietic stem and progenitor cells (HSPCs) shows great potential for the treatment of inborn metabolic diseases. Typical HSPC gene therapy approaches rely on constitutive promoters to express...
3.
Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes
Rogers G, Huang C, Clark R, Seclen E, Chen H, Cannon P
Mol Ther Methods Clin Dev
. 2021 Oct;
23:198-209.
PMID: 34703842
Adeno-associated virus serotype 6 (AAV6) is a valuable reagent for genome editing of hematopoietic cells due to its ability to serve as a homology donor template. However, a comprehensive study...
4.
5.
Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 and TIGIT CD4 T Cells
Llewellyn G, Seclen E, Wietgrefe S, Liu S, Chateau M, Pei H, et al.
J Virol
. 2019 Mar;
93(10).
PMID: 30842333
Combination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but does not result in virus eradication or a cure. A major contributing factor is the long-term persistence of a reservoir...
6.
Canny M, Moatti N, Wan L, Fradet-Turcotte A, Krasner D, Mateos-Gomez P, et al.
Nat Biotechnol
. 2017 Nov;
36(1):95-102.
PMID: 29176614
Programmable nucleases, such as Cas9, are used for precise genome editing by homology-dependent repair (HDR). However, HDR efficiency is constrained by competition from other double-strand break (DSB) repair pathways, including...
7.
Exline C, Yang S, Haworth K, Rengarajan S, Lopez L, Droniou M, et al.
Retrovirology
. 2015 Aug;
12:67.
PMID: 26248668
Background: The interferon-inducible factor BST-2/tetherin blocks the release of nascent virions from the surface of infected cells for certain enveloped virus families. The primate lentiviruses have evolved several counteracting mechanisms...
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9.
Plaza Z, Soriano V, Vispo E, Gonzalez M, Barreiro P, Seclen E, et al.
Antivir Ther
. 2012 Mar;
17(5):921-6.
PMID: 22436385
Background: Daclatasvir (BMS-790052) is an investigational molecule that inhibits the HCV NS5A protein and shows potent antiviral activity apparently across all HCV genotypes. Selection of drug resistance mutations has been...
10.
Seclen E, Soriano V, Gonzalez M, Gomez S, Thielen A, Poveda E
J Clin Microbiol
. 2011 Jul;
49(9):3380-2.
PMID: 21734029
The agreement between the position-specific scoring matrix (PSSM) and geno2pheno as tools for genotypic interpretation of HIV-1 tropism using 800 clinical specimens was assessed. There was an overall concordance of...