Edmund Carvalho
Overview
Explore the profile of Edmund Carvalho including associated specialties, affiliations and a list of published articles.
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14
Citations
505
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0
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Recent Articles
1.
Tomar D, Jana F, Dong Z, Quinn 3rd W, Jadiya P, Breves S, et al.
Cell Rep
. 2019 Mar;
26(13):3709-3725.e7.
PMID: 30917323
Mitochondrial Ca uniporter (MCU)-mediated Ca uptake promotes the buildup of reducing equivalents that fuel oxidative phosphorylation for cellular metabolism. Although MCU modulates mitochondrial bioenergetics, its function in energy homeostasis in ...
2.
Sarkar A, Carvalho E, DSouza A, Banerjee R
Nanomedicine (Lond)
. 2019 Mar;
14(7):871-887.
PMID: 30895865
Aim: To provide multilayered combination therapies encompassing nanoparticles and organic peptides and to assess their efficacy in the treatment of arthritis. Materials & Methods: Fish oil protein (FP) was isolated...
3.
Woods J, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan S, et al.
ACS Cent Sci
. 2019 Jan;
5(1):153-166.
PMID: 30693334
Mitochondrial Ca (Ca) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human...
4.
Shanmughapriya S, Tomar D, Dong Z, Slovik K, Nemani N, Natarajaseenivasan K, et al.
Nat Commun
. 2018 Aug;
9(1):3449.
PMID: 30158529
Although many factors contribute to cellular differentiation, the role of mitochondria Ca dynamics during development remains unexplored. Because mammalian embryonic epiblasts reside in a hypoxic environment, we intended to understand...
5.
Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves S, et al.
Cell Rep
. 2018 Apr;
23(4):1005-1019.
PMID: 29694881
Mitochondria shape cytosolic calcium ([Ca]) transients and utilize the mitochondrial Ca ([Ca]) in exchange for bioenergetics output. Conversely, dysregulated [Ca] causes [Ca] overload and induces permeability transition pore and cell...
6.
Dong Z, Shanmughapriya S, Tomar D, Siddiqui N, Lynch S, Nemani N, et al.
Mol Cell
. 2017 Mar;
65(6):1014-1028.e7.
PMID: 28262504
Ca dynamics and oxidative signaling are fundamental mechanisms for mitochondrial bioenergetics and cell function. The MCU complex is the major pathway by which these signals are integrated in mitochondria. Whether...
7.
Lee S, Shanmughapriya S, Mok M, Dong Z, Tomar D, Carvalho E, et al.
Cell Chem Biol
. 2016 Aug;
23(9):1157-1169.
PMID: 27569754
Calcium (Ca(2+)) flux into the matrix is tightly controlled by the mitochondrial Ca(2+) uniporter (MCU) due to vital roles in cell death and bioenergetics. However, the precise atomic mechanisms of...
8.
Sehgal R, Carvalho E, Banerjee R
ACS Appl Mater Interfaces
. 2016 May;
8(22):13735-47.
PMID: 27176647
Nanocomposite scaffolds are studied widely due to their resemblance with the natural extracellular matrix of bone; but their use as a bone tissue engineered scaffold is clinically hampered due to...
9.
Carvalho E, Verma P, Hourigan K, Banerjee R
Regen Med
. 2015 Nov;
10(8):1025-43.
PMID: 26563414
It is estimated that by 2030, almost 23.6 million people will perish from cardiovascular disease, according to the WHO. The review discusses advances in stem cell therapy for myocardial infarction,...
10.
Singh P, Ghosh D, Tewari D, Mohite G, Carvalho E, Jha N, et al.
PLoS One
. 2015 Mar;
10(3):e0120346.
PMID: 25803428
Conversion of amyloid fibrils by many peptides/proteins involves cytotoxic helix-rich oligomers. However, their toxicity and biophysical studies remain largely unknown due to their highly dynamic nature. To address this, we...