Peter B Stathopulos
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Explore the profile of Peter B Stathopulos including associated specialties, affiliations and a list of published articles.
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84
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Recent Articles
1.
Colussi D, Grainger R, Noble M, Lake T, Junop M, Stathopulos P
Comput Struct Biotechnol J
. 2025 Feb;
27:190-213.
PMID: 40017731
The regulatory mechanisms of the mitochondrial calcium uniporter complex (mtCU), the predominant channel mediating calcium (Ca ) flux into the matrix, are critical for bioenergetics and cell fate. The pore-forming...
2.
Lin Q, Colussi D, Stathopulos P
FEBS Lett
. 2025 Feb;
PMID: 39927520
Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) plays a critical role in mitochondrial function, with haploinsufficiency linked to Wolf-Hirschhorn syndrome. Here, we present the solution NMR structure of the calcium...
3.
Lucaciu S, Leighton S, Wong R, Sekar V, Hauser A, Lai N, et al.
J Physiol
. 2025 Jan;
PMID: 39817844
Here we characterize seven Cx30.3 gene variants (R22H, S26Y, P61R, C86S, E99K, T130M and M190L) clinically associated with the rare skin disorder erythrokeratodermia variabilis et progressiva (EKVP) in tissue-relevant and...
4.
Lin Q, Colussi D, Lake T, Stathopulos P
Structure
. 2024 Sep;
32(11):2063-2082.e5.
PMID: 39317198
AlphaFold can accurately predict static protein structures but does not account for solvent conditions. Human leucine zipper EF-hand transmembrane protein-1 (LETM1) has one sequence-identifiable EF-hand but how calcium (Ca) affects...
5.
Uthayabalan S, Lake T, Stathopulos P
Protein Sci
. 2024 Jul;
33(8):e5108.
PMID: 38989547
Mitochondrial magnesium (Mg) is a crucial modulator of protein stability, enzymatic activity, ATP synthesis, and cell death. Mitochondrial RNA splicing protein 2 (MRS2) is the main Mg channel in the...
6.
Colussi D, Stathopulos P
J Physiol
. 2024 Jun;
602(14):3315-3339.
PMID: 38857425
Increased malignancy and poor treatability associated with solid tumour cancers have commonly been attributed to mitochondrial calcium (Ca) dysregulation. The mitochondrial Ca uniporter complex (mtCU) is the predominant mode of...
7.
Sallinger M, Humer C, Ong H, Narayanasamy S, Lin Q, Fahrner M, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2318874121.
PMID: 38753510
The single-pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the endoplasmic reticulum (ER) membrane, possesses two main functions: It senses the ER-Ca concentration and directly binds to the...
8.
Noble M, Colussi D, Junop M, Stathopulos P
iScience
. 2024 May;
27(5):109699.
PMID: 38706857
The mitochondrial calcium (Ca) uniporter (MCU) complex is regulated via integration of the MCU dominant negative beta subunit (MCUb), a low conductance paralog of the main MCU pore forming protein....
9.
Leighton S, Wong R, Lucaciu S, Hauser A, Johnston D, Stathopulos P, et al.
J Cell Sci
. 2024 Mar;
137(7).
PMID: 38533727
Connexins are channel-forming proteins that function to facilitate gap junctional intercellular communication. Here, we use dual cell voltage clamp and dye transfer studies to corroborate past findings showing that Cx31.1...
10.
Vishnu N, Venkatesan M, Madaris T, Venkateswaran M, Stanley K, Ramachandran K, et al.
Mol Cell
. 2024 Mar;
84(7):1321-1337.e11.
PMID: 38513662
Intracellular Mg (Mg) is bound with phosphometabolites, nucleic acids, and proteins in eukaryotes. Little is known about the intracellular compartmentalization and molecular details of Mg transport into/from cellular organelles such...