Edith G McGeer
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Explore the profile of Edith G McGeer including associated specialties, affiliations and a list of published articles.
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43
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2744
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Recent Articles
1.
McGeer P, Lee M, Kennedy K, McGeer E
J Clin Med
. 2020 Feb;
9(2).
PMID: 32019214
Background: Saliva, the most readily available body fluid, is the product of genes which are in constant activity throughout life. Measurement of saliva can predict the onset of some diseases...
2.
McGeer P, Guo J, Lee M, Kennedy K, McGeer E
J Alzheimers Dis
. 2017 Nov;
62(3):1219-1222.
PMID: 29103042
Alzheimer's disease (AD) is characterized by deposits of amyloid-β protein (Aβ) in brain which become foci of inflammation. Neurons are destroyed by this inflammatory process, leading to the cognitive deficits...
3.
McGeer P, Lee M, McGeer E
Neurobiol Aging
. 2017 Jan;
52:12-22.
PMID: 28104543
Complement is the backbone of our innate immune system. It is of ancient evolutionary origin, being traced back to horseshoe crabs 350 million years ago. It consists today of more...
4.
Lee M, Guo J, Kennedy K, McGeer E, McGeer P
J Alzheimers Dis
. 2016 Oct;
55(3):1175-1182.
PMID: 27792013
We have developed a non-invasive method of diagnosing Alzheimer's disease (AD), which can also predict the risk of its future onset. It is based on measuring salivary levels of amyloid-β...
5.
McGeer P, Rogers J, McGeer E
J Alzheimers Dis
. 2016 Oct;
54(3):853-857.
PMID: 27716676
Two basic discoveries spurred research into inflammation as a driving force in the pathogenesis of Alzheimer's disease (AD). The first was the identification of activated microglia in association with the...
6.
Lee M, McGeer E, McGeer P
Neurobiol Aging
. 2016 Aug;
46:113-23.
PMID: 27479153
Epidemiologic studies indicate that coffee consumption reduces the risk of Parkinson's disease and Alzheimer's disease. To determine the factors involved, we examined the protective effects of coffee components. The test...
7.
Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases
Lee M, McGeer E, McGeer P
J Neuroinflammation
. 2016 Feb;
13:32.
PMID: 26856696
Background: Sodium thiosulfate (STS) is an industrial chemical which has also been approved for the treatment of certain rare medical conditions. These include cyanide poisoning and calciphylaxis in hemodialysis patients...
8.
OHare E, Jeggo R, Kim E, Barbour B, Walczak J, Palmer P, et al.
Neuropharmacology
. 2015 May;
100:124-30.
PMID: 26025659
Bexarotene has been reported to reduce brain amyloid-β (Aβ) levels and to improve cognitive function in transgenic mouse models of Alzheimer's disease (AD). Four groups failed to fully replicate the...
9.
Hashioka S, McGeer E, Miyaoka T, Wake R, Horiguchi J, McGeer P
CNS Neurol Disord Drug Targets
. 2015 Feb;
14(2):251-6.
PMID: 25687700
Activated astrocytes, which can also be referred to as reactive astrocytes or astrogliosis, have been identified in affected regions of common neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic...
10.
McGeer P, McGeer E
Expert Opin Ther Targets
. 2014 Dec;
19(4):497-506.
PMID: 25435348
Introduction: Activated microglia are associated with the progression of Alzheimer's disease (AD), as well as many other neurodegenerative diseases of aging. Microglia are therefore key targets for therapeutic intervention. Areas...