Eberhard Unger
Overview
Explore the profile of Eberhard Unger including associated specialties, affiliations and a list of published articles.
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25
Citations
369
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Recent Articles
1.
Prinz H, Schmidt P, Bohm K, Baasner S, Muller K, Gerlach M, et al.
Bioorg Med Chem
. 2011 Jun;
19(14):4183-91.
PMID: 21705223
A novel series of phenylimino-10H-anthracen-9-ones and 9-(phenylhydrazone)-9,10-anthracenediones were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. The 10-(3-hydroxy-4-methoxy-phenylimino)-10H-anthracen-9-one 15h and...
2.
Nickel H, Schmidt P, Bohm K, Baasner S, Muller K, Gerlach M, et al.
Eur J Med Chem
. 2010 Jun;
45(8):3420-38.
PMID: 20537765
A novel series of 1,5- and 1,8-disubstituted 10-benzylidene-10H-anthracen-9-ones and 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones was synthesized to assess the substituent effects on biological activity. The 3-hydroxy-2,4-dimethoxy-benzylidene analogue 16 h displayed strong antiproliferative activity against...
3.
Chinali A, Vater W, Rudakoff B, Sponner A, Unger E, Grosse F, et al.
J Mol Evol
. 2010 Mar;
70(4):325-38.
PMID: 20349054
The spider silk gene family to the current date has been developed by gene duplication and homogenization events as well as conservation of crucial sequence parts. These evolutionary processes have...
4.
Prinz H, Schmidt P, Bohm K, Baasner S, Muller K, Unger E, et al.
J Med Chem
. 2009 Feb;
52(5):1284-94.
PMID: 19220018
A series of 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones were synthesized and evaluated for interactions with tubulin and for antiproliferative activity against a panel of human and rodent tumor cell lines. The 4-methoxy analogue 17b...
5.
Stoiber T, Unger E, Dorn S, Degen G, Bolt H
Arch Toxicol
. 2008 Feb;
82(9):601-6.
PMID: 18253717
A recent concept connecting the lipophilicity of organic chemicals with their genotoxicity on a chromosomal level implies that the lipophilic character of organic chemicals determines a certain background of chromosomal...
6.
Zuse A, Schmidt P, Baasner S, Bohm K, Muller K, Gerlach M, et al.
J Med Chem
. 2007 Nov;
50(24):6059-66.
PMID: 17973361
Benzenesulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone were prepared and found to inhibit microtubule formation by an in vitro tubulin polymerization assay. Several analogues showed potent cytotoxic activity in an assay...
7.
Sponner A, Vater W, Monajembashi S, Unger E, Grosse F, Weisshart K
PLoS One
. 2007 Oct;
2(10):e998.
PMID: 17912375
Albeit silks are fairly well understood on a molecular level, their hierarchical organisation and the full complexity of constituents in the spun fibre remain poorly defined. Here we link morphological...
8.
Beeg J, Klumpp S, Dimova R, Serral Gracia R, Unger E, Lipowsky R
Biophys J
. 2007 Sep;
94(2):532-41.
PMID: 17872957
The movements of beads pulled by several kinesin-1 (conventional kinesin) motors are studied both theoretically and experimentally. While the velocity is approximately independent of the number of motors pulling the...
9.
Zuse A, Schmidt P, Baasner S, Bohm K, Muller K, Gerlach M, et al.
J Med Chem
. 2006 Dec;
49(26):7816-25.
PMID: 17181164
A novel series of 9-benzylidene-naphtho[2,3-b]thiophen-4-ones and structurally related compounds were synthesized and evaluated for their ability to inhibit tubulin polymerization. The 4-hydroxy-3,5-dimethoxy-benzylidene analogue 15d was identified as a potent cytotoxic...
10.
Korosoglou G, Behrens S, Bekeredjian R, Hardt S, Hagenmueller M, Dinjus E, et al.
Ultrasound Med Biol
. 2006 Oct;
32(10):1473-8.
PMID: 17045866
Microbubble-based ultrasound contrast agents can be used for specific site targeting, but demonstrate time-limited opacification. We have previously demonstrated the potential of gold-bound microtubules to provide a stable ultrasound contrast...