Eamonn J Dickson
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Explore the profile of Eamonn J Dickson including associated specialties, affiliations and a list of published articles.
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1420
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Recent Articles
1.
Voelker T, Voelker T, Westhoff M, Del Villar S, Thai P, Chiamvimonvat N, et al.
bioRxiv
. 2025 Mar;
PMID: 40060428
Contractile dysfunction, hypertrophy, and cell death during heart failure are linked to altered Ca2+ handling, and elevated levels of the hormone angiotensin II (AngII), which signals through Gq-coupled AT1 receptors,...
2.
Spooner H, Costa A, Westhoff M, Hernandez-Gonzalez A, Ibrahimkhail H, Yarov-Yarovoy V, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2413308122.
PMID: 39869803
The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.2 channels must be expressed on the sarcolemma; thus...
3.
Flores-Tamez V, Martin-Aragon Baudel M, Hong J, Taylor J, Ren L, Le T, et al.
J Am Heart Assoc
. 2024 Oct;
13(20):e035375.
PMID: 39377203
Background: Increased vascular Ca1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are...
4.
Woltz R, Zheng Y, Choi W, Ngo K, Trinh P, Ren L, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(39):e2318900121.
PMID: 39288178
Small-conductance Ca-activated K channels (SK, K2) are gated solely by intracellular microdomain Ca. The channel has emerged as a therapeutic target for cardiac arrhythmias. Calmodulin (CaM) interacts with the CaM...
5.
Spooner H, Costa A, Gonzalez A, Ibrahimkhail H, Yarov-Yarovoy V, Horne M, et al.
bioRxiv
. 2024 Sep;
PMID: 39229175
Significance Statement: The L-type Ca channel, Ca 1.2, plays an essential role in excitation-contraction coupling in the heart and in part regulates the overall strength of contraction during basal and...
6.
Westhoff M, Del Villar S, Voelker T, Thai P, Spooner H, Costa A, et al.
Nat Commun
. 2024 May;
15(1):4397.
PMID: 38782927
No abstract available.
7.
Casas M, Dickson E
Neurosci Insights
. 2024 May;
19:26331055241252772.
PMID: 38737295
Cholesterol and calcium play crucial roles as integral structural components and functional signaling entities within the central nervous system. Disruption in cholesterol homeostasis has been linked to Alzheimer's, Parkinson's, and...
8.
Westhoff M, Del Villar S, Voelker T, Thai P, Spooner H, Costa A, et al.
Nat Commun
. 2024 Apr;
15(1):3528.
PMID: 38664444
Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of...
9.
Horvath J, Casas M, Kutchukian C, Sanchez S, Pergande M, Cologna S, et al.
Cell Rep
. 2023 Oct;
42(10):113244.
PMID: 37838947
Anomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson's disease (PD). Despite its strong link to disease, the precise...
10.
Casas M, Murray K, Hino K, Vierra N, Simo S, Trimmer J, et al.
Nat Commun
. 2023 Jul;
14(1):4553.
PMID: 37507375
Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is...