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Silvia G Del Villar

Explore the profile of Silvia G Del Villar including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 61
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Recent Articles
1.
Voelker T, Voelker T, Westhoff M, Del Villar S, Thai P, Chiamvimonvat N, et al.
bioRxiv . 2025 Mar; PMID: 40060428
Contractile dysfunction, hypertrophy, and cell death during heart failure are linked to altered Ca2+ handling, and elevated levels of the hormone angiotensin II (AngII), which signals through Gq-coupled AT1 receptors,...
2.
Rhana P, Matsumoto C, Fong Z, Costa A, Del Villar S, Dixon R, et al.
Proc Natl Acad Sci U S A . 2024 Jun; 121(25):e2318535121. PMID: 38865270
The heart beats approximately 100,000 times per day in humans, imposing substantial energetic demands on cardiac muscle. Adenosine triphosphate (ATP) is an essential energy source for normal function of cardiac...
3.
Westhoff M, Del Villar S, Voelker T, Thai P, Spooner H, Costa A, et al.
Nat Commun . 2024 May; 15(1):4397. PMID: 38782927
No abstract available.
4.
Westhoff M, Del Villar S, Voelker T, Thai P, Spooner H, Costa A, et al.
Nat Commun . 2024 Apr; 15(1):3528. PMID: 38664444
Cardiac dysfunction is a hallmark of aging in humans and mice. Here we report that a two-week treatment to restore youthful Bridging Integrator 1 (BIN1) levels in the hearts of...
5.
Voelker T, Del Villar S, Westhoff M, Costa A, Coleman A, Hell J, et al.
Proc Natl Acad Sci U S A . 2023 Mar; 120(14):e2221242120. PMID: 36976770
Ca1.2 channels are critical players in cardiac excitation-contraction coupling, yet we do not understand how they are affected by an important therapeutic target of heart failure drugs and regulator of...
6.
Del Villar S, Voelker T, Westhoff M, Reddy G, Spooner H, Navedo M, et al.
Proc Natl Acad Sci U S A . 2021 Feb; 118(7). PMID: 33558236
The number and activity of Ca1.2 channels in the cardiomyocyte sarcolemma tunes the magnitude of Ca-induced Ca release and myocardial contraction. β-Adrenergic receptor () activation stimulates sarcolemmal insertion of Ca1.2....
7.
Ito D, Hannigan K, Ghosh D, Xu B, Del Villar S, Xiang Y, et al.
J Physiol . 2019 Feb; 597(8):2139-2162. PMID: 30714156
Key Points: Prevailing dogma holds that activation of the β-adrenergic receptor/cAMP/protein kinase A signalling pathway leads to enhanced L-type Ca 1.2 channel activity, resulting in increased Ca influx into ventricular...
8.
Del Villar S, Jones A
Int J Mol Sci . 2018 Aug; 19(8). PMID: 30065178
The insect GABA receptor, RDL (resistance to dieldrin), is a cys-loop ligand-gated ion channel (cysLGIC) that plays a central role in neuronal signaling, and is the target of several classes...