E L Roberts Jr
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Explore the profile of E L Roberts Jr including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
178
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Recent Articles
1.
Chih C, LIPTON P, Roberts Jr E
Trends Neurosci
. 2001 Sep;
24(10):573-8.
PMID: 11576670
Glucose has long been considered the substrate for neuronal energy metabolism in the brain. Recently, an alternative explanation of energy metabolism in the active brain, the astrocyte-neuron lactate shuttle hypothesis,...
2.
Comparison of glucose and lactate as substrates during NMDA-induced activation of hippocampal slices
Chih C, He J, Sly T, Roberts Jr E
Brain Res
. 2001 Feb;
893(1-2):143-54.
PMID: 11223002
It has been postulated that lactate released from astrocytes may be the preferred metabolic substrate for neurons, particularly during intense neuronal activity (the astrocyte-neuron lactate shuttle hypothesis). We examined this...
3.
Roberts Jr E, He J, Chih C
Brain Res
. 2000 Sep;
875(1-2):171-4.
PMID: 10967313
The purpose of this study was to see how the nominal removal of bicarbonate (HCO(-)(3)) from the extracellular space of brain tissue influenced recovery of brain tissue from anoxia. Removal...
4.
Roberts Jr E
Methods
. 1999 Jun;
18(2):150-9.
PMID: 10356345
Aging alters ion regulation in brain tissue. This article describes methods useful for studying such age-related changes in the rat hippocampal slice preparation. Topics considered include (a) selection of appropriate...
5.
Roberts Jr E, Wisotzky D, Chih C
Brain Res
. 1998 Jun;
791(1-2):321-4.
PMID: 9593969
We examined whether age-related differences in N-methyl-D-aspartate (NMDA) receptor-mediated neurotoxicity contribute to the increased vulnerability of the aged brain to anoxic damage. In both adult and aged hippocampal slices, NMDA...
6.
Roberts Jr E, He J, Chih C
Brain Res
. 1998 May;
783(1):44-50.
PMID: 9479044
In this study we investigated in rat hippocampal slices (1) how glucose availability affected tissue acidosis during and after anoxia, (2) whether the onset of anoxic depolarization was associated with...
7.
Roberts Jr E, Chih C
Brain Res
. 1998 Feb;
779(1-2):271-5.
PMID: 9473691
We examined the hypothesis that aging alters the capacity of brain tissue to buffer intracellular pH changes. Intracellular buffering power was determined in hippocampal slices from young adult and aged...
8.
Roberts Jr E, Chih C
J Cereb Blood Flow Metab
. 1997 May;
17(5):560-6.
PMID: 9183294
Changes in intracellular and extracellular pH may influence the vulnerability of brain tissue to anoxic or ischemic damage. In the present study, we investigated whether the increased vulnerability of aged...
9.
Roberts Jr E, Chih C, Rosenthal M
Adv Exp Med Biol
. 1997 Jan;
411:83-9.
PMID: 9269414
No abstract available.
10.
Roberts Jr E, Sick T
Brain Res
. 1996 Oct;
735(2):339-42.
PMID: 8911676
We investigated whether aging changed H+ homeostasis in hippocampal slices bathed in HEPES buffer. Intracellular pH in hippocampal slices from rats aged 26-27 months (7.06 +/- 0.02) was significantly lower...