E Keats Shwab
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Explore the profile of E Keats Shwab including associated specialties, affiliations and a list of published articles.
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18
Citations
723
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Recent Articles
1.
Shwab E, Man Z, Gingerich D, Gamache J, Garrett M, Serrano G, et al.
bioRxiv
. 2025 Jan;
PMID: 39764045
Introduction: Alzheimer's disease (AD), Dementia with Lewy bodies (DLB), and Parkinson's disease (PD) represent a spectrum of neurodegenerative disorders (NDDs). Here, we performed the first direct comparison of their transcriptomic...
2.
Li B, Wang S, Kerman B, Hugo C, Shwab E, Shu C, et al.
bioRxiv
. 2024 Nov;
PMID: 39605544
Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer's disease (AD) but much less is known on the key cell types and pathways driving mechanisms of senescence...
3.
Shwab E, Gingerich D, Man Z, Gamache J, Garrett M, Crawford G, et al.
Acta Neuropathol Commun
. 2024 Jul;
12(1):111.
PMID: 38956662
The genetic architecture of Parkinson's disease (PD) is complex and multiple brain cell subtypes are involved in the neuropathological progression of the disease. Here we aimed to advance our understanding...
4.
Gamache J, Gingerich D, Shwab E, Barrera J, Garrett M, Hume C, et al.
Cell Biosci
. 2023 Oct;
13(1):185.
PMID: 37789374
Background: The genetic underpinnings of late-onset Alzheimer's disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain...
5.
Shwab E, Juvvadi P, Shaheen S, Allen 4th J, Waitt G, Soderblom E, et al.
J Fungi (Basel)
. 2022 Apr;
8(4).
PMID: 35448585
Cellular recycling via autophagy-associated proteins is a key catabolic pathway critical to invasive fungal pathogen growth and virulence in the nutrient-limited host environment. Protein kinase A (PKA) is vital for...
6.
Shaheen S, Juvvadi P, Allen 4th J, Shwab E, Cole D, Asfaw Y, et al.
Antimicrob Agents Chemother
. 2021 Jul;
65(10):e0068221.
PMID: 34310205
Invasive aspergillosis (IA) due to Aspergillus fumigatus is a deadly infection for which new antifungal therapies are needed. Here, we demonstrate the efficacy of a Gwt1 inhibitor, APX2041, and its...
7.
Shwab E, Juvvadi P, Waitt G, Shaheen S, Allen 4th J, Soderblom E, et al.
mBio
. 2020 Dec;
11(6).
PMID: 33323509
Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus...
8.
Roundtree M, Juvvadi P, Shwab E, Cole D, Steinbach W
Antimicrob Agents Chemother
. 2020 Jul;
64(10).
PMID: 32660997
Triazole antifungals are the primary therapeutic option against invasive aspergillosis. However, resistance to azoles has increased dramatically over the last decade. Azole resistance is known to primarily occur due to...
9.
Shwab E, Juvvadi P, Waitt G, Soderblom E, Barrington B, Asfaw Y, et al.
Mol Microbiol
. 2019 Mar;
112(1):62-80.
PMID: 30927289
Calcium signaling through calcineurin and its major transcription factor (TF), CrzA, is integral to hyphal growth, stress response and virulence of the pathogenic fungus Aspergillus fumigatus, the leading etiology of...
10.
Shwab E, Saraf P, Zhu X, Zhou D, McFerrin B, Ajzenberg D, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(29):E6956-E6963.
PMID: 29967142
A majority of emerging infectious diseases in humans are zoonoses. Understanding factors that influence the emergence and transmission of zoonoses is pivotal for their prevention and control. is one of...