E J Morcillo
Overview
Explore the profile of E J Morcillo including associated specialties, affiliations and a list of published articles.
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Articles
86
Citations
610
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Recent Articles
1.
Milara J, Gabarda E, Juan G, Ortiz J, Guijarro R, Martorell M, et al.
Eur Respir J
. 2011 Aug;
39(4):927-38.
PMID: 21828025
The endothelin (ET) system contributes to lung vascular tension and remodelling in smokers and chronic obstructive pulmonary disease (COPD) patients. This study examined the effect of cigarette smoke (CS) on...
2.
Milara J, Navarro A, Almudever P, Lluch J, Morcillo E, Cortijo J
Clin Exp Allergy
. 2011 Mar;
41(4):535-46.
PMID: 21395877
Background: Oxidative stress is present in airway diseases such as severe asthma or Chronic Obstructive Pulmonary Disease and contributes to the low response to glucocorticoids through the down-regulation of histone...
3.
Milara J, Ortiz J, Juan G, Guijarro R, Almudever P, Martorell M, et al.
Br J Pharmacol
. 2010 Aug;
161(7):1599-615.
PMID: 20698855
Background And Purpose: Pulmonary arteries from smokers and chronic obstructive pulmonary disease patients show abnormal endothelium-dependent vascular reactivity. We studied the effect of cigarette smoke extract (CSE) on endothelin receptor...
4.
Cortijo J, Mata M, Milara J, Donet E, Gavalda A, Miralpeix M, et al.
Eur Respir J
. 2010 Jun;
37(2):244-54.
PMID: 20525722
Mucus hypersecretion and mucin MUC5AC overexpression are pathological features of chronic obstructive pulmonary disease (COPD). This study examines the inhibitory effect of aclidinium, a new long-acting muscarinic antagonist, on MUC5AC...
5.
Cortijo J, Milara J, Mata M, Donet E, Gavara N, Peel S, et al.
Chem Biol Interact
. 2009 Sep;
183(1):25-33.
PMID: 19781536
Environmental exposure to nickel is associated to respiratory disorders and potential toxicity in the lung but molecular mechanisms remain incompletely explored. The extracellular Ca(2+)-sensing receptor (CaSR) is widely distributed and...
6.
Martinez-Losa M, Cortijo J, Piqueras L, Sanz M, Morcillo E
Clin Exp Allergy
. 2009 Feb;
39(4):537-46.
PMID: 19222497
Background: Eosinophils are prominent effectors of allergic inflammation. Taurine-chloramine (TauCl), a derivative of the amino acid taurine, shows antioxidant properties in different cell systems but its effects on eosinophils have...
7.
Cortijo J, Iranzo A, Milara X, Mata M, Cerda-Nicolas M, Ruiz-Sauri A, et al.
Br J Pharmacol
. 2009 Jan;
156(3):534-44.
PMID: 19154443
Background And Purpose: The effects of a phosphodiesterase 4 (PDE4) inhibitor, roflumilast, on bleomycin-induced lung injury were explored in 'preventive' and 'therapeutic' protocols and compared with glucocorticoids. Experimental Approach: Roflumilast...
8.
Sanz M, Cortijo J, Taha M, Cerda-Nicolas M, Schatton E, Burgbacher B, et al.
Br J Pharmacol
. 2007 Aug;
152(4):481-92.
PMID: 17704822
Background And Purpose: The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte-endothelial cell interactions and endothelial permeability in vivo and in vitro. Experimental Approach: In...
9.
Martinez-Losa M, Cortijo J, Juan G, Ramon M, Sanz M, Morcillo E
Eur Respir J
. 2007 May;
30(3):436-42.
PMID: 17504796
Eosinophils are oxidant-sensitive cells considered relevant in allergic inflammation. The present study aimed to examine the effects of the antioxidant N-acetyl-L-cysteine (NAC) on constitutive and cytokine-delayed apoptosis in human isolated...
10.
Martinez-Losa M, Cortijo J, Juan G, OConnor J, Sanz M, Santangelo F, et al.
Clin Exp Allergy
. 2007 Apr;
37(5):714-22.
PMID: 17456219
Background: Oxidative stress appears to be relevant in the pathogenesis of inflammation in allergic diseases like bronchial asthma. Eosinophils are oxidant-sensitive cells considered as key effectors in allergic inflammation. Objective:...