E E Largis
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Explore the profile of E E Largis including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
152
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Recent Articles
1.
Kolodgie F, Katocs Jr A, Largis E, Wrenn S, Cornhill J, Herderick E, et al.
Arterioscler Thromb Vasc Biol
. 1996 Dec;
16(12):1454-64.
PMID: 8977449
While a number of studies have presented detailed examinations of lesion development in the cholesterol-fed rabbit, individual variability in response to cholesterol feeding and type of lesion produced relative to...
2.
DOLAN J, Muenkel H, Burns M, Pellegrino S, Fraser C, Pietri F, et al.
J Pharmacol Exp Ther
. 1994 Jun;
269(3):1000-6.
PMID: 7912272
The beta-1, beta-2 and beta-3 adrenergic properties of several benzodioxole-containing phenethanolamines were determined in vitro in both functional and binding assays. In addition, two of the compounds were evaluated for...
3.
Bloom J, Dutia M, Johnson B, Wissner A, Burns M, Largis E, et al.
J Med Chem
. 1992 Aug;
35(16):3081-4.
PMID: 1354264
No abstract available.
4.
DeVries V, Bloom J, Dutia M, Katocs Jr A, Largis E
J Med Chem
. 1989 Oct;
32(10):2318-25.
PMID: 2795605
The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone....
5.
Largis E, Wang C, DeVries V, Schaffer S
J Lipid Res
. 1989 May;
30(5):681-90.
PMID: 2760542
CL 277,082 (I) was found to be a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in microsomes from a variety of tissues with IC50 values of 0.14 microM...
6.
DeVries V, Schaffer S, Largis E, Dutia M, Wang C, Bloom J, et al.
J Med Chem
. 1986 Jul;
29(7):1131-3.
PMID: 3100794
No abstract available.
7.
DeVries V, Largis E, Miner T, SHEPHERD R, Upeslacis J
J Med Chem
. 1983 Oct;
26(10):1411-21.
PMID: 6604818
The synthesis of a series of analogues in which the alkyl group of cetaben is substituted with various functional groups or replaced entirely by a functionalized alkanoyl moiety is described....
8.
Albright J, DeVries V, Du M, Largis E, Miner T, Reich M, et al.
J Med Chem
. 1983 Oct;
26(10):1393-411.
PMID: 6604817
The synthesis of a series of analogues in which the carboxylic acid group of cetaben is replaced by carboxylate ester, carboxamide, or a variety of other substituent groups is described....
9.
Albright J, DeVries V, Largis E, Miner T, Reich M, Schaffer S, et al.
J Med Chem
. 1983 Oct;
26(10):1378-93.
PMID: 6604816
The syntheses of a series of (aralkylamino)- and (alkylamino)benzoic acids, as well as the corresponding esters and sodium salts, are described. The compounds were evaluated in vivo in rats for...
10.
Wang C, Largis E, Schaffer S
Artery
. 1981 Jan;
9(5):358-71.
PMID: 6976159
Normal aortic endothelial cells cultured in serum-free medium elaborate a factor(s) which cause the proliferation of smooth muscle cells or 3T3 cells grown in medium containing plasma-derived serum. For smooth...