Dylan Mooijman
Overview
Explore the profile of Dylan Mooijman including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
315
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0
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Recent Articles
1.
De Jonghe J, Opzoomer J, Vilas-Zornoza A, Nilges B, Crane P, Vicari M, et al.
Cell Genom
. 2024 Dec;
4(12):100723.
PMID: 39667347
Understanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging...
2.
Beumer J, Geurts M, Geurts V, Andersson-Rolf A, Akkerman N, Vollmy F, et al.
Science
. 2024 Oct;
386(6719):341-348.
PMID: 39418382
Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric inhibitory protein (GIP), which regulate multiple...
3.
De Jonghe J, Opzoomer J, Vilas-Zornoza A, Crane P, Nilges B, Vicari M, et al.
Nat Biotechnol
. 2024 Jul;
42(7):1017-1023.
PMID: 39020213
No abstract available.
4.
Kester L, de Barbanson B, Lyubimova A, Chen L, van der Schrier V, Alemany A, et al.
Cell Genom
. 2023 Feb;
2(2):100096.
PMID: 36778661
Organoid evolution models complemented with integrated single-cell sequencing technology provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and tumor evolution. Here, we conduct a parallel evolution experiment to mimic...
5.
Sen M, Mooijman D, Chialastri A, Boisset J, Popovic M, Heindryckx B, et al.
Nat Commun
. 2021 Feb;
12(1):1286.
PMID: 33627650
DNA methylation (5mC) is central to cellular identity. The global erasure of 5mC from the parental genomes during preimplantation mammalian development is critical to reset the methylome of gametes to...
6.
Hollmann N, Jagtap P, Masiewicz P, Guitart T, Simon B, Provaznik J, et al.
Cell Rep
. 2020 Jul;
32(3):107930.
PMID: 32697992
RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability define the specificity of...
7.
Markodimitraki C, Rang F, Rooijers K, de Vries S, Chialastri A, de Luca K, et al.
Nat Protoc
. 2020 May;
15(6):1922-1953.
PMID: 32350457
Protein-DNA interactions are essential for establishing cell type-specific chromatin architecture and gene expression. We recently developed scDam&T-seq, a multi-omics method that can simultaneously quantify protein-DNA interactions and the transcriptome in...
8.
Rooijers K, Markodimitraki C, Rang F, de Vries S, Chialastri A, de Luca K, et al.
Nat Biotechnol
. 2019 Jun;
37(7):766-772.
PMID: 31209373
Protein-DNA interactions are critical to the regulation of gene expression, but it remains challenging to define how cell-to-cell heterogeneity in protein-DNA binding influences gene expression variability. Here we report a...
9.
Mooijman D, Dey S, Boisset J, Crosetto N, van Oudenaarden A
Nat Biotechnol
. 2016 Jun;
34(8):852-6.
PMID: 27347753
The epigenetic DNA modification 5-hydroxymethylcytosine (5hmC) has crucial roles in development and gene regulation. Quantifying the abundance of this epigenetic mark at the single-cell level could enable us to understand...
10.
Klemm S, Semrau S, Wiebrands K, Mooijman D, Faddah D, Jaenisch R, et al.
Nat Methods
. 2014 Apr;
11(5):549-551.
PMID: 24681693
We have developed a quantitative technique for sorting cells on the basis of endogenous RNA abundance, with a molecular resolution of 10-20 transcripts. We demonstrate efficient and unbiased RNA extraction...