Dustin R Wakeman
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Explore the profile of Dustin R Wakeman including associated specialties, affiliations and a list of published articles.
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21
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1362
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Recent Articles
11.
Wakeman D, Redmond Jr D, Dodiya H, Sladek Jr J, Leranth C, Teng Y, et al.
Stem Cells Transl Med
. 2014 Apr;
3(6):692-701.
PMID: 24744393
Transplanted multipotent human fetal neural stem cells (hfNSCs) significantly improved the function of parkinsonian monkeys in a prior study primarily by neuroprotection, with only 3%-5% of cells expressing a dopamine...
12.
Mattis V, Wakeman D, Tom C, Dodiya H, Yeung S, Tran A, et al.
Exp Neurol
. 2014 Jan;
254:90-8.
PMID: 24440640
Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance...
13.
Wakeman D, Weiss S, Sladek J, Elsworth J, Bauereis B, Leranth C, et al.
Cell Transplant
. 2013 Apr;
23(8):981-94.
PMID: 23562290
A human embryonic stem cell (HESC) line, H1, was studied after differentiation to a dopaminergic phenotype in vitro in order to carry out in vivo studies in Parkinsonian monkeys. To...
14.
Teng Y, Yu D, Ropper A, Li J, Kabatas S, Wakeman D, et al.
Curr Neuropharmacol
. 2012 Jun;
9(4):574-85.
PMID: 22654717
We here propose an updated concept of stem cells (SCs), with an emphasis on neural stem cells (NSCs). The conventional view, which has touched principally on the essential property of...
15.
Kriks S, Shim J, Piao J, Ganat Y, Wakeman D, Xie Z, et al.
Nature
. 2011 Nov;
480(7378):547-51.
PMID: 22056989
Human pluripotent stem cells (PSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal motoneurons or midbrain dopamine...
16.
Wakeman D, Dodiya H, Kordower J
Mt Sinai J Med
. 2011 Jan;
78(1):126-58.
PMID: 21259269
Parkinson's disease is a progressive neurodegenerative disorder affecting, in part, dopaminergic motor neurons of the ventral midbrain and their terminal projections that course to the striatum. Symptomatic strategies focused on...
17.
Chernov A, Baranovskaya S, Golubkov V, Wakeman D, Snyder E, Williams R, et al.
J Biol Chem
. 2010 Apr;
285(25):19647-59.
PMID: 20404328
Epigenetic parameters (DNA methylation, histone modifications, and miRNAs) play a significant role in cancer. To identify the common epigenetic signatures of both the individual matrix metalloproteinases (MMPs) and the additional...
18.
Redmond Jr D, Weiss S, Elsworth J, Roth R, Wakeman D, Bjugstad K, et al.
Rejuvenation Res
. 2010 Apr;
13(2-3):188-94.
PMID: 20370501
Parkinson disease (PD) is a neurodegenerative disorder that provides a useful model for testing cell replacement strategies to rejuvenate the affected dopaminergic neural systems, which have been destroyed by aging...
19.
Espinosa-Jeffrey A, Wakeman D, Kim S, Snyder E, de Vellis J
Curr Protoc Stem Cell Biol
. 2009 Sep;
Chapter 2:Unit 2D.4.
PMID: 19725014
Here we document protocols for the production, isolation, and maintenance of the oligodendrocyte phenotype from rodent and human neural stem cells. Our unique method relies on a series of chemically...
20.
Wakeman D, Hofmann M, Redmond Jr D, Teng Y, Snyder E
Curr Protoc Stem Cell Biol
. 2009 May;
Chapter 2:Unit2D.3.
PMID: 19455542
Human neural stem/precursor cells (hNSC/hNPC) have been targeted for application in a variety of research models and as prospective candidates for cell-based therapeutic modalities in central nervous system (CNS) disorders....