Duncan H Mak
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Explore the profile of Duncan H Mak including associated specialties, affiliations and a list of published articles.
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30
Citations
921
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Recent Articles
1.
Shi W, Wang Y, Zhao Y, Kim J, Li H, Meng C, et al.
Sci Transl Med
. 2023 May;
15(695):eadf6724.
PMID: 37163614
Checkpoint immunotherapy has yielded meaningful responses across many cancers but has shown modest efficacy in advanced prostate cancer. B7 homolog 3 protein (B7-H3/) is an immune checkpoint molecule and has...
2.
Carter B, Mak P, Tao W, Ostermann L, Mak D, Ke B, et al.
Haematologica
. 2023 Feb;
108(9):2513-2519.
PMID: 36727398
No abstract available.
3.
Carter B, Mak P, Tao W, Zhang Q, Ruvolo V, Kuruvilla V, et al.
Mol Cancer Ther
. 2022 Apr;
21(6):879-889.
PMID: 35364607
MCL-1 is known to play a major role in resistance to BCL-2 inhibition, but the contribution of other BCL-2 family proteins has not been fully explored. We, here, demonstrate the...
4.
Carter B, Mak P, Mu H, Wang X, Tao W, Mak D, et al.
Haematologica
. 2019 Aug;
105(5):1274-1284.
PMID: 31371419
Although highly effective, BCR-ABL1 tyrosine kinase inhibitors do not target chronic myeloid leukemia (CML) stem cells. Most patients relapse upon tyrosine kinase inhibitor therapy cessation. We reported previously that combined...
5.
Kannan S, Aitken M, Herbrich S, Golfman L, Hall M, Mak D, et al.
Mol Cancer Ther
. 2019 Jun;
18(9):1615-1627.
PMID: 31227645
In B-cell acute lymphoblastic leukemia (B-ALL), activation of Notch signaling leads to cell-cycle arrest and apoptosis. We aimed to harness knowledge acquired by understanding a mechanism of Notch-induced cell death...
6.
Han L, Zhang Q, Dail M, Shi C, Cavazos A, Ruvolo V, et al.
Haematologica
. 2019 May;
105(3):697-707.
PMID: 31123034
The pathogenesis of acute myeloid leukemia (AML) involves serial acquisition of mutations controlling several cellular processes, requiring combination therapies affecting key downstream survival nodes in order to treat the disease...
7.
Jiang X, Mak P, Mu H, Tao W, Mak D, Kornblau S, et al.
Clin Cancer Res
. 2018 Feb;
24(10):2417-2429.
PMID: 29463558
Wnt/β-catenin signaling is required for leukemic stem cell function. mutations are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling increases β-catenin nuclear localization and transcriptional activity. FLT3 tyrosine...
8.
Lyons Y, Pradeep S, Wu S, Haemmerle M, Hansen J, Wagner M, et al.
Oncotarget
. 2017 Dec;
8(57):96496-96505.
PMID: 29228548
Anti-angiogenesis therapy has shown clinical benefit in patients with high-grade serous ovarian cancer (HGSC), but adaptive resistance rapidly emerges. Thus, approaches to overcome such resistance are needed. We developed the...
9.
McCarthy R, Mak D, Burks J, Barton M
Sci Rep
. 2017 Jun;
7(1):3779.
PMID: 28630464
Mass cytometry presents an exceptional opportunity to interrogate the biology of highly heterogeneous cell populations, owing to the ability to collect highly parametric proteomic data at a single cell level....
10.
Carter B, Mak P, Wang X, Yang H, Garcia-Manero G, Mak D, et al.
Mol Cancer Ther
. 2017 Mar;
16(6):1133-1144.
PMID: 28270436
Although overexpression/activation of focal adhesion kinase (FAK) is widely known in solid tumors to control cell growth, survival, invasion, metastasis, gene expression, and stem cell self-renewal, its expression and function...