Duncan G G McMillan
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Explore the profile of Duncan G G McMillan including associated specialties, affiliations and a list of published articles.
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37
Citations
556
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Recent Articles
11.
Marsden S, McMillan D, Hanefeld U
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33207817
The synthetic properties of the Thiamine diphosphate (ThDP)-dependent pyruvate dehydrogenase E1 subunit from (PDH E1) was assessed for carboligation reactions with aliphatic ketoacids. Due to its role in metabolism, PDH...
12.
Zarco-Zavala M, Watanabe R, McMillan D, Suzuki T, Ueno H, Mendoza-Hoffmann F, et al.
Proc Natl Acad Sci U S A
. 2020 Nov;
117(47):29647-29657.
PMID: 33168750
The rotation of F-ATPase (PdF) was studied using single-molecule microscopy. At all concentrations of adenosine triphosphate (ATP) or a slowly hydrolyzable ATP analog (ATPγS), above or below , PdF showed...
13.
Krah A, van der Hoeven B, Mestrom L, Tonin F, Knobel K, Bond P, et al.
Biochim Biophys Acta Gen Subj
. 2020 Oct;
1865(1):129766.
PMID: 33069831
Background: Prediction of ligand binding and design of new function in enzymes is a time-consuming and expensive process. Crystallography gives the impression that proteins adopt a fixed shape, yet enzymes...
14.
de Jong S, van den Broek M, Merkel A, de la Torre Cortes P, Kalamorz F, Cook G, et al.
Extremophiles
. 2020 Oct;
24(6):923-935.
PMID: 33030592
The aerobic thermoalkaliphile Caldalkalibacillus thermarum strain TA2.A1 is a member of a separate order of alkaliphilic bacteria closely related to the Bacillales order. Efforts to relate the genomic information of...
15.
Krah A, Huber R, McMillan D, Bond P
Chembiochem
. 2020 Jul;
21(22):3249-3254.
PMID: 32608105
The ϵ subunit of ATP synthases has been proposed to regulate ATP hydrolysis in bacteria. Prevailing evidence supports the notion that when the ATP concentration falls below a certain threshold,...
16.
Godoy-Hernandez A, Tate D, McMillan D
Biochemistry
. 2019 Oct;
58(42):4272-4275.
PMID: 31592658
Type-II NADH:quinone oxidoreductases (NDH-2s) are an important element of microbial pathogen electron transport chains and an attractive drug target. Despite being widely studied, its mechanism and catalysis are still poorly...
17.
Urbani A, Giorgio V, Carrer A, Franchin C, Arrigoni G, Jiko C, et al.
Nat Commun
. 2019 Sep;
10(1):4341.
PMID: 31554800
The molecular identity of the mitochondrial megachannel (MMC)/permeability transition pore (PTP), a key effector of cell death, remains controversial. By combining highly purified, fully active bovine F-ATP synthase with preformed...
18.
Hards K, McMillan D, Schurig-Briccio L, Gennis R, Lill H, Bald D, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(28):7326-7331.
PMID: 29941569
Bedaquiline (BDQ), an inhibitor of the mycobacterial FF-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently...
19.
Krah A, Zarco-Zavala M, McMillan D
Open Biol
. 2018 May;
8(5).
PMID: 29769322
ATP synthases catalyse the formation of ATP, the most common chemical energy storage unit found in living cells. These enzymes are driven by an electrochemical ion gradient, which allows the...
20.
Noji H, Ueno H, McMillan D
Biophys Rev
. 2017 Apr;
9(2):103-118.
PMID: 28424741
The F-ATPase is the catalytic portion of the FF ATP synthase and acts as a rotary molecular motor when it hydrolyzes ATP. Two decades have passed since the single-molecule rotation...