Alexander Krah
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Explore the profile of Alexander Krah including associated specialties, affiliations and a list of published articles.
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40
Citations
565
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Recent Articles
1.
Krah A, Grover V, Fong T, Bond P, Gruber G
Structure
. 2025 Feb;
33(3):594-600.e3.
PMID: 39892380
The Acinetobacter baumannii FF-ATP synthase is essential for the opportunistic human pathogen. Its membrane-embedded F domain consists of the c-ring and subunit a. The c-ring translocates protons via a conserved...
2.
Koh J, Itahana Y, Krah A, Mostafa H, Ong M, Iwamura S, et al.
Commun Chem
. 2024 Jul;
7(1):158.
PMID: 39003409
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current...
3.
Shivgan A, Marzinek J, Krah A, Matsudaira P, Verma C, Bond P
J Chem Theory Comput
. 2024 Feb;
20(8):3308-3321.
PMID: 38358378
Proteoglycans contain glycosaminoglycans (GAGs) which are negatively charged linear polymers made of repeating disaccharide units of uronic acid and hexosamine units. They play vital roles in numerous physiological and pathological...
4.
Ragunathan P, Sae-Lao P, Hamela C, Alcaraz M, Krah A, Poh W, et al.
J Biol Chem
. 2024 Jan;
300(2):105618.
PMID: 38176652
The FF-ATP synthase engine is essential for viability and growth of nontuberculous mycobacteria (NTM) by providing the biological energy ATP and keeping ATP homeostasis under hypoxic stress conditions. Here, we...
5.
Krah A, Ragunathan P, Bond P, Gruber G
Biochem Biophys Res Commun
. 2023 Nov;
690:149249.
PMID: 38000294
The anti-tuberculosis therapeutic bedaquiline (BDQ) is used against Mycobacterium abscessus. In M. abscessus BDQ is only bacteriostatic and less potent compared to M. tuberculosis or M. smegmatis. Here we demonstrate...
6.
Krah A, Vogelaar T, de Jong S, Claridge J, Bond P, McMillan D
Front Mol Biosci
. 2023 Mar;
10:1059673.
PMID: 36923639
It is a conjecture that the ε subunit regulates ATP hydrolytic function of the FF ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended...
7.
Krah A, Gruber G, Bond P
Curr Res Struct Biol
. 2022 Oct;
4:278-284.
PMID: 36186842
Tuberculosis (TB), the deadly disease caused by (), kills more people worldwide than any other bacterial infectious disease. There has been a recent resurgence of TB drug discovery activities, resulting...
8.
Tupina D, Krah A, Marzinek J, Zuzic L, Moverley A, Constantinidou C, et al.
Curr Res Struct Biol
. 2022 Mar;
4:59-67.
PMID: 35345452
Flagella are necessary for bacterial movement and contribute to various aspects of virulence. They are complex cylindrical structures built of multiple molecular rings with self-assembly properties. The flagellar rotor is...
9.
Chan K, Su C, Krah A, Phua S, Yeo J, Ling W, et al.
Molecules
. 2020 Dec;
25(24).
PMID: 33322154
The ongoing development of drug resistance in HIV continues to push for the need of alternative drug targets in inhibiting HIV. One such target is the Reverse transcriptase (RT) enzyme...
10.
Krah A, van der Hoeven B, Mestrom L, Tonin F, Knobel K, Bond P, et al.
Biochim Biophys Acta Gen Subj
. 2020 Oct;
1865(1):129766.
PMID: 33069831
Background: Prediction of ligand binding and design of new function in enzymes is a time-consuming and expensive process. Crystallography gives the impression that proteins adopt a fixed shape, yet enzymes...