Douglas P Lee
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Explore the profile of Douglas P Lee including associated specialties, affiliations and a list of published articles.
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11
Citations
658
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Recent Articles
1.
Liu G, Lee D, Schmidt E, Prasad G
Bioinform Biol Insights
. 2019 Nov;
13:1177932219882961.
PMID: 31666793
Existing US epidemiological data demonstrate that consumption of smokeless tobacco, particularly moist snuff, is less harmful than cigarette smoking. However, the molecular and biochemical changes due to moist snuff consumption...
2.
Freemerman A, Zhao L, Pingili A, Teng B, Cozzo A, Fuller A, et al.
J Immunol
. 2019 Jan;
202(4):1265-1286.
PMID: 30659108
Macrophages (MΦs) are heterogeneous and metabolically flexible, with metabolism strongly affecting immune activation. A classic response to proinflammatory activation is increased flux through glycolysis with a downregulation of oxidative metabolism,...
3.
Johnson A, Qin Y, Cozzo A, Freemerman A, Huang M, Zhao L, et al.
Mol Metab
. 2016 Jul;
5(7):506-526.
PMID: 27408776
Objective: A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically activated MΦs (CAM), which...
4.
Boudonck K, Rose D, Karoly E, Lee D, Lawton K, Lapinskas P
Bioanalysis
. 2010 Nov;
1(9):1645-63.
PMID: 21083109
The identification of biomarkers of drug-induced kidney injury is an area of intensive focus in drug development. Traditional markers of renal function, including blood urea nitrogen and serum creatinine, are...
5.
Wetmore D, Joseloff E, Pilewski J, Lee D, Lawton K, Mitchell M, et al.
J Biol Chem
. 2010 Aug;
285(40):30516-22.
PMID: 20675369
Cystic fibrosis (CF) is a life-shortening disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. To gain an understanding of the epithelial dysfunction associated with...
6.
Barnes V, Teles R, Trivedi H, DeVizio W, Xu T, Lee D, et al.
J Periodontol
. 2010 May;
81(9):1273-9.
PMID: 20450373
Background: Periodontal disease has been studied primarily from clinical outcomes in lengthy human studies. Comprehensive biochemical profiling (metabolomics) has become a powerful tool for disease characterization and biomarker discovery. In...
7.
Wang S, Lee D, Gong N, Schwerbrock N, Mashek D, Gonzalez-Baro M, et al.
Arch Biochem Biophys
. 2007 Aug;
465(2):347-58.
PMID: 17689486
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step in glycerolipid synthesis. Several mammalian GPAT activities have been recognized, including N-ethylmaleimide (NEM)-sensitive isoforms in microsomes and mitochondria and an NEM-resistant...
8.
9.
Lu B, Kelher M, Lee D, Lewin T, Coleman R, Choy P, et al.
Biochem Cell Biol
. 2004 Oct;
82(5):569-76.
PMID: 15499385
Tafazzins, a group of proteins that are defective in patients with Barth syndrome, are produced by alternate splicing of the gene G4.5 or TAZ. RT-PCR and transcription-coupled in vitro translation...
10.
Lewin T, Schwerbrock N, Lee D, Coleman R
J Biol Chem
. 2004 Jan;
279(14):13488-95.
PMID: 14724270
Glycerol-3-phosphate acyltransferase (GPAT) catalyzes the initial and rate-limiting step of glycerolipid synthesis. Two distinct GPAT isoenzymes had been identified in mammalian tissues, an N-ethylmaleimide (NEM)-sensitive isoform in the endoplasmic reticulum...