Douglas J Epstein
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Explore the profile of Douglas J Epstein including associated specialties, affiliations and a list of published articles.
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42
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1777
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Recent Articles
11.
Muthu V, Rohacek A, Yao Y, Rakowiecki S, Brown A, Zhao Y, et al.
Development
. 2019 Sep;
146(18).
PMID: 31488567
The mammalian cochlea develops from a ventral outgrowth of the otic vesicle in response to Shh signaling. Mouse embryos lacking Shh or its essential signal transduction components display cochlear agenesis;...
12.
Corman T, Bergendahl S, Epstein D
Development
. 2018 Oct;
145(21).
PMID: 30291164
Sonic hedgehog (Shh) plays well characterized roles in brain and spinal cord development, but its functions in the hypothalamus have been more difficult to elucidate owing to the complex neuroanatomy...
13.
Rohacek A, Bebee T, Tilton R, Radens C, McDermott-Roe C, Peart N, et al.
Dev Cell
. 2017 Nov;
43(3):318-331.e5.
PMID: 29107558
Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in auditory development remains unclear. We performed whole-exome sequencing in individuals with sensorineural hearing loss (SNHL) and...
14.
Kahn B, Corman T, Lovelace K, Hong M, Krauss R, Epstein D
Dis Model Mech
. 2016 Dec;
10(1):29-37.
PMID: 27935818
Septo-optic dysplasia (SOD) is a congenital disorder characterized by optic nerve, pituitary and midline brain malformations. The clinical presentation of SOD is highly variable with a poorly understood etiology. The...
15.
Yao Y, Minor P, Zhao Y, Jeong Y, Pani A, King A, et al.
Nat Genet
. 2016 Jul;
48(8):970.
PMID: 27463400
No abstract available.
16.
Yao Y, Minor P, Zhao Y, Jeong Y, Pani A, King A, et al.
Nat Genet
. 2016 Apr;
48(5):575-80.
PMID: 27064252
Genomic approaches have predicted hundreds of thousands of tissue-specific cis-regulatory sequences, but the determinants critical to their function and evolutionary history are mostly unknown. Here we systematically decode a set...
17.
Brown A, Rakowiecki S, Li J, Epstein D
Dev Biol
. 2015 Jan;
399(1):177-187.
PMID: 25592224
Wnt1 and Wnt3a secreted from the dorsal neural tube were previously shown to regulate a gene expression program in the dorsal otic vesicle that is necessary for vestibular morphogenesis (Riccomagno...
18.
Trowe M, Zhao L, Weiss A, Christoffels V, Epstein D, Kispert A
Development
. 2013 May;
140(11):2299-309.
PMID: 23674600
Tbx2 and Tbx3 are two highly related members of the T-box transcription factor gene family that regulate patterning and differentiation of a number of tissue rudiments in the mouse. Both...
19.
Rakowiecki S, Epstein D
Development
. 2013 Mar;
140(8):1730-9.
PMID: 23487315
The morphogenetic program that shapes the three semicircular canals (SSCs) must be executed with extreme precision to satisfy their complex vestibular function. The SSCs emerge from epithelial outgrowths of the...
20.
Lee B, Rizzoti K, Kwon D, Kim S, Oh S, Epstein D, et al.
Dev Biol
. 2012 May;
366(2):393-403.
PMID: 22561201
Six6, a sine oculis homeobox protein, plays a crucial and conserved role in the development of the forebrain and eye. To understand how the expression of Six6 is regulated during...