Douglas J Bartels
Overview
Explore the profile of Douglas J Bartels including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
339
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0
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Recent Articles
1.
Evans I, Sun X, Liang B, Vegter A, Guo L, Lynch T, et al.
JCI Insight
. 2024 Apr;
9(8.
PMID: 38646935
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, with F508del being the most prevalent mutation. The combination of CFTR modulators (potentiator and correctors)...
2.
Luo M, Ma J, Cheng X, Wu S, Bartels D, Guay D, et al.
Hum Gene Ther
. 2023 Jun;
34(15-16):705-718.
PMID: 37335046
Gene editing strategies are attractive for treating genetic pulmonary diseases such as cystic fibrosis (CF). However, challenges have included the development of safe and effective vector systems for gene editing...
3.
Picchio G, De Meyer S, Dierynck I, Ghys A, Gritz L, Kieffer T, et al.
J Clin Virol
. 2014 Jan;
59(3):148-55.
PMID: 24462470
Background: Telaprevir-based therapy is associated with rapid decline in HCV RNA, enabling the application of early futility rules. Objectives: To familiarize physicians with this paradigm, a comprehensive analysis of the...
4.
De Meyer S, Dierynck I, Ghys A, Beumont M, Daems B, Van Baelen B, et al.
Hepatology
. 2012 Jul;
56(6):2106-15.
PMID: 22806681
Unlabelled: In the Phase 3 REALIZE study, 662 genotype 1 hepatitis C virus (HCV)-infected patients with prior peginterferon/ribavirin treatment failure (including relapsers, partial, and null responders) were randomized to 12...
5.
Grossman T, Bartels D, Mullin S, Gross C, Parsons J, Liao Y, et al.
Antimicrob Agents Chemother
. 2006 Nov;
51(2):657-66.
PMID: 17116675
A structure-guided drug design approach was used to optimize a novel series of aminobenzimidazoles that inhibit the essential ATPase activities of bacterial DNA gyrase and topoisomerase IV and that show...
6.
Yarwood J, Bartels D, Volper E, Greenberg E
J Bacteriol
. 2004 Mar;
186(6):1838-50.
PMID: 14996815
Several serious diseases are caused by biofilm-associated Staphylococcus aureus, infections in which the accessory gene regulator (agr) quorum-sensing system is thought to play an important role. We studied the contribution...
7.
Dong X, Mitchell D, Lobo S, Zhao L, Bartels D, Deschenes R
Mol Cell Biol
. 2003 Aug;
23(18):6574-84.
PMID: 12944483
Subcellular localization of Ras proteins to the plasma membrane is accomplished in part by covalent attachment of a farnesyl moiety to the conserved CaaX box cysteine. Farnesylation targets Ras to...