Douglas H Sieglaff
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Explore the profile of Douglas H Sieglaff including associated specialties, affiliations and a list of published articles.
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20
Citations
532
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Recent Articles
1.
Quintela M, Sieglaff D, Gazze A, Zhang A, Gonzalez D, Francis L, et al.
Nanomedicine
. 2019 Feb;
17:254-265.
PMID: 30759370
New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone...
2.
Zhao W, Beers D, Hooten K, Sieglaff D, Zhang A, Kalyana-Sundaram S, et al.
JAMA Neurol
. 2017 Apr;
74(6):677-685.
PMID: 28437540
Importance: Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons. Patients with ALS have persistent peripheral and central inflammatory...
3.
Dave B, Gonzalez D, Liu Z, Li X, Wong H, Granados S, et al.
J Natl Cancer Inst
. 2017 Jan;
109(6).
PMID: 28040796
Background: Metaplastic breast cancer is one of the most therapeutically challenging forms of breast cancer because of its highly heterogeneous and chemoresistant nature. We have previously demonstrated that ribosomal protein...
4.
Cvoro A, Bajic A, Zhang A, Simon M, Golic I, Sieglaff D, et al.
PLoS One
. 2016 Oct;
11(10):e0164407.
PMID: 27732649
Thyroid hormone (TH) receptors (TRs α and β) are homologous ligand-dependent transcription factors (TFs). While the TRs display distinct actions in development, metabolic regulation and other processes, comparisons of TRα...
5.
Puhl A, Milton F, Cvoro A, Sieglaff D, Campos J, Bernardes A, et al.
Nucl Recept Signal
. 2015 Oct;
13:e004.
PMID: 26445566
Non-steroidal anti-inflammatory drugs (NSAIDs) display anti-inflammatory, antipyretic and analgesic properties by inhibiting cyclooxygenases and blocking prostaglandin production. Previous studies, however, suggested that some NSAIDs also modulate peroxisome proliferator activated receptors...
6.
Suh J, Chattopadhyay A, Sieglaff D, Samaniego C, Cox M, Webb P
PLoS One
. 2015 Sep;
10(9):e0137103.
PMID: 26332122
The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to arrest of an AR/chaperone complex in the cytoplasm....
7.
Milton F, Cvoro A, Amato A, Sieglaff D, Filgueira C, Arumanayagam A, et al.
Biochem Biophys Res Commun
. 2015 Jul;
464(3):718-23.
PMID: 26168725
Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ) agonists that improve insulin resistance but trigger side effects such as weight gain, edema, congestive heart failure and bone loss. GQ-16 is...
8.
Zhang A, Sieglaff D, York J, Suh J, Ayers S, Winnier G, et al.
J Endocrinol
. 2014 Dec;
224(3):289-301.
PMID: 25501997
Thyroid hormone (TH) acts through specific receptors (TRs), which are conditional transcription factors, to induce fibroblast growth factor 21 (FGF21), a peptide hormone that is usually induced by fasting and...
9.
Cvoro A, Devito L, Milton F, Noli L, Zhang A, Filippi C, et al.
Stem Cells
. 2014 Oct;
33(2):416-28.
PMID: 25330987
Biological processes require close cooperation of multiple transcription factors that integrate different signals. Thyroid hormone receptors (TRs) induce Krüppel-like factor 9 (KLF9) to regulate neurogenesis. Here, we show that triiodothyronine...
10.
Suh J, Sieglaff D, Zhang A, Xia X, Cvoro A, Winnier G, et al.
PLoS One
. 2013 Aug;
8(7):e70097.
PMID: 23922917
Sirtuin 1 (SIRT1) NAD(+)-dependent deacetylase regulates energy metabolism by modulating expression of genes involved in gluconeogenesis and other liver fasting responses. While many effects of SIRT1 on gene expression are...