Alexander S Raikhel
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Explore the profile of Alexander S Raikhel including associated specialties, affiliations and a list of published articles.
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92
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4950
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Recent Articles
1.
Cheng Y, Wang X, Ding Y, Zhang H, Jia Z, Raikhel A
Proc Natl Acad Sci U S A
. 2025 Feb;
122(9):e2411758122.
PMID: 39993202
Female mosquitoes are vectors of many devastating human diseases because they require blood feeding to initiate reproduction. Thus, elucidation of molecular mechanisms managing female mosquito reproduction is essential. Although the...
2.
Wang J, Zhong Z, He Y, Tian J, Wang Y, Raikhel A
Proc Natl Acad Sci U S A
. 2025 Jan;
122(2):e2411688122.
PMID: 39792288
Female mosquitoes require a vertebrate blood meal to activate reproduction, transmitting numerous devastating human diseases. Vitellogenesis is a central event of female reproduction that involves the massive production of vitellogenin...
3.
Geng D, Wang X, Lyu X, Raikhel A, Zou Z
PLoS Genet
. 2024 Mar;
20(3):e1011196.
PMID: 38466721
Hematophagous mosquitoes require vertebrate blood for their reproductive cycles, making them effective vectors for transmitting dangerous human diseases. Thus, high-intensity metabolism is needed to support reproductive events of female mosquitoes....
4.
Sun X, Wang X, Shi K, Lyu X, Sun J, Raikhel A, et al.
Nat Commun
. 2024 Jan;
15(1):106.
PMID: 38168045
Aedes aegypti are vectors for several arboviruses infecting hundreds of millions of people annually. Controlling mosquito populations by regulating their reproduction is a potential strategy to minimize viral transmission in...
5.
Ling L, Raikhel A
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2303234120.
PMID: 37579141
female mosquitoes require vertebrate blood for their egg production and consequently they become vectors of devastating human diseases. Amino acids (AAs) and nutrients originating from a blood meal activate vitellogenesis...
6.
Wang Y, Chang M, Wang M, Ji Y, Sun X, Raikhel A, et al.
Microbiol Spectr
. 2022 Dec;
11(1):e0312322.
PMID: 36537797
The Aedes aegypti mosquito transmits devastating flaviviruses, such as Zika, dengue, and yellow fever viruses. For more effective control of the vector, the pathogenicity of Beauveria bassiana, a fungus commonly...
7.
Wang M, Wang Y, Chang M, Wang X, Shi Z, Raikhel A, et al.
PLoS Pathog
. 2022 Sep;
18(9):e1010837.
PMID: 36137163
The balance between immunity and reproduction is essential for many key physiological functions. We report that to maintain an optimal fertility, 20-hydroxyecdysone (20E) and the ecdysone receptor (EcR) downregulate the...
8.
Roy S, Saha T, Ha J, Banerjee R, Aksoy E, Kulkarni A, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(11):e2116787119.
PMID: 35254892
SignificanceHematophagous mosquitoes spread devastating viral diseases. Upon blood feeding, a steroid hormone, 20-hydroxyecdysone (20E), initiates a reproductive program during which thousands of genes are differentially expressed. While 20E-mediated gene activation...
9.
Aksoy E, Raikhel A
Proc Natl Acad Sci U S A
. 2021 Jul;
118(29).
PMID: 34266957
MicroRNAs (miRNAs) are small noncoding RNAs that play critical roles in controlling posttranscriptional gene regulation and have a profound effect on mosquito reproduction and metabolism. Juvenile hormone (JH) is critical...
10.
He Y, Aksoy E, Ding Y, Raikhel A
Proc Natl Acad Sci U S A
. 2021 Jun;
118(26).
PMID: 34155112
Female mosquitoes transmit numerous devastating human diseases because they require vertebrate blood meal for egg development. MicroRNAs (miRNAs) play critical roles across multiple reproductive processes in female mosquitoes. However, how...