Douglas E Raines
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Explore the profile of Douglas E Raines including associated specialties, affiliations and a list of published articles.
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69
Citations
902
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Recent Articles
1.
Pence A, Hoyt H, McGrath M, Forman S, Raines D
J Pharmacol Exp Ther
. 2022 Sep;
383(3):238-245.
PMID: 36167415
Although propofol is among the most commonly administered general anesthetics, its mechanism of action is not fully understood. It has been hypothesized that propofol acts via a similar mechanism as...
2.
Pence A, McGrath M, Lee S, Raines D
Ther Adv Endocrinol Metab
. 2022 Feb;
13:20420188211058583.
PMID: 35186251
Cushing's syndrome (CS) is an endocrine disease characterized by excessive adrenocortical steroid production. One of the mainstay pharmacological treatments for CS are steroidogenesis enzyme inhibitors, including the antifungal agent ketoconazole...
3.
McGrath M, Hoyt H, Pence A, Forman S, Raines D
Br J Pharmacol
. 2021 Aug;
178(24):4842-4858.
PMID: 34386973
Background And Purpose: In addition to binding to the classical high-affinity extracellular benzodiazepine binding site of the GABA receptor, some benzodiazepines occupy transmembrane inter-subunit anaesthetic sites that bind etomidate (β...
4.
Dalia A, Raines D
J Cardiothorac Vasc Anesth
. 2021 Feb;
35(4):1086-1088.
PMID: 33579572
No abstract available.
5.
McGrath M, Hoyt H, Pence A, Jayakar S, Zhou X, Forman S, et al.
Anesthesiology
. 2020 Jun;
133(3):583-594.
PMID: 32541553
Background: Recent cryo-electron microscopic imaging studies have shown that in addition to binding to the classical extracellular benzodiazepine binding site of the α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor, diazepam...
6.
McGrath M, Tolia M, Raines D
Pharmacol Rep
. 2020 Feb;
72(1):260-266.
PMID: 32016849
Background: Many sedative-hypnotic agents are thought to act by positively modulating γ-aminobutyric acid type A (GABA) receptors. However, for many agents, the location(s) of the binding site(s) responsible for such...
7.
McGrath M, Pence A, Raines D
Trends Pharmacol Sci
. 2019 Oct;
40(11):809-811.
PMID: 31623940
All currently available general anesthetics produce potentially deadly side effects. Unfortunately, few approaches have been developed to design safer ones, despite important advances in anesthetic mechanisms research. Cayla and colleagues...
8.
McGrath M, Hofmann A, Raines D
BMC Pharmacol Toxicol
. 2019 Aug;
20(1):48.
PMID: 31383012
Background: Cushing's syndrome is an endocrine disorder characterized by the overproduction of adrenocortical steroids. Steroidogenesis enzyme inhibitors are the mainstays of pharmacological treatment. Unfortunately, they produce significant side effects. Among...
9.
Valk B, McGrath M, LeHoux D, Zerler B, Marota J, Raines D
Anesthesiology
. 2019 Jun;
131(2):287-304.
PMID: 31166238
Background: The etomidate analog ABP-700 produces involuntary muscle movements that could be manifestations of seizures. To define the relationship (if any) between involuntary muscle movements and seizures, electroencephalographic studies were...
10.
McGrath M, Yu Z, Jayakar S, Ma C, Tolia M, Zhou X, et al.
Anesthesiology
. 2018 Jul;
129(5):959-969.
PMID: 30052529
What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Naphthalene-etomidate, an etomidate analog containing a bulky phenyl ring substituent group, possesses very low...