Doug N Halligan
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Explore the profile of Doug N Halligan including associated specialties, affiliations and a list of published articles.
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7
Citations
119
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Recent Articles
1.
Brown E, Rowan C, Strowitzki M, Fagundes R, Faber K, Guntsch A, et al.
FASEB J
. 2020 Jan;
34(3):3732-3742.
PMID: 31944416
The HIF hydroxylase enzymes (PHD1-3 and FIH) are cellular oxygen-sensors which confer hypoxic-sensitivity upon the hypoxia-inducible factors HIF-1α and HIF-2α. Microenvironmental hypoxia has a strong influence on the epithelial and...
2.
Harnoss J, Gebhardt J, Radhakrishnan P, Leowardi C, Burmeister J, Halligan D, et al.
Inflamm Bowel Dis
. 2019 Oct;
26(2):192-205.
PMID: 31618435
Background: Pouchitis is the most common long-term complication after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) or familial adenomatous polyposis (FAP), which can eventually progress to...
3.
Halligan D, Khan M, Brown E, Rowan C, Coulter I, Doherty G, et al.
Am J Physiol Gastrointest Liver Physiol
. 2019 May;
317(2):G90-G97.
PMID: 31070931
Inflammatory bowel disease (IBD) is characterized by epithelial barrier dysfunction with resultant inflammation as the mucosal immune system becomes exposed to luminal antigens. The hydroxylase inhibitor dimethyloxalylglycine (DMOG) reduces symptoms...
4.
Crifo B, Schaible B, Brown E, Halligan D, Scholz C, Fitzpatrick S, et al.
J Immunol
. 2019 Feb;
202(5):1521-1530.
PMID: 30700584
Hypoxia is a common and prominent feature of the microenvironment at sites of bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing enzymes...
5.
Manresa M, Smith L, Casals-Diaz L, Fagundes R, Brown E, Radhakrishnan P, et al.
Allergy
. 2018 Nov;
74(4):753-766.
PMID: 30394557
Background: When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular...
6.
Halligan D, Murphy S, Taylor C
Semin Immunol
. 2016 Oct;
28(5):469-477.
PMID: 27717536
Crosstalk between metabolic and immune pathways has recently become appreciated to be key to the regulation of host defence. The hypoxia-inducible factor (HIF) is a transcription factor which was initially...
7.
Scholz C, Rodriguez J, Pickel C, Burr S, Fabrizio J, Nolan K, et al.
PLoS Biol
. 2016 Jan;
14(1):e1002347.
PMID: 26752685
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is...