Raphael R Fagundes
Overview
Explore the profile of Raphael R Fagundes including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
89
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0
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Recent Articles
1.
Fagundes R, Zaldumbide A, Taylor C
Trends Pharmacol Sci
. 2024 Aug;
45(9):798-810.
PMID: 39127527
Type 1 diabetes (T1D) is a common autoimmune disease in which dysregulated glucose metabolism is a key feature. T1D is both poorly understood and in need of improved therapeutics. Hypoxia...
2.
Dekkers M, Lambooij J, Pu X, Fagundes R, Enciso-Martinez A, Kats K, et al.
Front Immunol
. 2024 Aug;
15:1393248.
PMID: 39114661
Objective: Beta cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In recent years, the role played by beta cells in the...
3.
Geertsema S, Fagundes R, Otten A, Dijkstra G, Faber K, Bourgonje A
Inflamm Bowel Dis
. 2024 Mar;
30(4):693-694.
PMID: 38442894
No abstract available.
4.
Fagundes R, Bravo-Ruiseco G, Hu S, Kierans S, Weersma R, Taylor C, et al.
Front Microbiol
. 2024 Jan;
14:1298304.
PMID: 38163085
Introduction: Intestinal epithelial cells produce interleukin-18 (IL-18), a key factor in promoting epithelial barrier integrity. Here, we analyzed the potential role of gut bacteria and the hypoxia-inducible factor 1α (HIF1α)...
5.
Kierans S, Fagundes R, Malkov M, Sparkes R, Dillon E, Smolenski A, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(35):e2208117120.
PMID: 37603756
The metabolic adaptation of eukaryotic cells to hypoxia involves increasing dependence upon glycolytic adenosine triphosphate (ATP) production, an event with consequences for cellular bioenergetics and cell fate. This response is...
6.
Fagundes R, Belt S, Bakker B, Dijkstra G, Harmsen H, Faber K
Trends Microbiol
. 2023 Aug;
32(2):178-189.
PMID: 37596118
Human gut bacteria produce metabolites that support energy and carbon metabolism of colonic epithelial cells. While butyrate is commonly considered the primary fuel, it alone cannot meet all the carbon...
7.
Geertsema S, Bourgonje A, Fagundes R, Gacesa R, Weersma R, Goor H, et al.
Trends Mol Med
. 2023 Aug;
29(10):830-842.
PMID: 37558549
Oxidative stress (OS) is an important pathophysiological mechanism in inflammatory bowel disease (IBD). However, clinical trials investigating compounds directly targeting OS in IBD yielded mixed results. The NRF2 (nuclear factor...
8.
Fagundes R, Bourgonje A, Hu S, Barbieri R, Jansen B, Sinnema N, et al.
Front Physiol
. 2022 Jun;
13:889091.
PMID: 35755436
Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that...
9.
Fagundes R, Bourgonje A, Saeed A, Vich Vila A, Plomp N, Blokzijl T, et al.
Gut Microbes
. 2021 Nov;
13(1):1993582.
PMID: 34793284
Many chronic diseases are associated with decreased abundance of the gut commensal . This strict anaerobe can grow on dietary fibers, e.g., prebiotics, and produce high levels of butyrate, often...
10.
Smith-Cortinez N, Fagundes R, Gomez V, Kong D, de Waart D, Heegsma J, et al.
FASEB J
. 2020 Nov;
35(2):e21219.
PMID: 33236467
Liver fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly composed of collagen. Hepatic stellate cells (HSCs) mediate liver fibrosis by secreting collagen. Vitamin C (ascorbic acid) is...