Dorthe H Larsen
Overview
Explore the profile of Dorthe H Larsen including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
311
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Recent Articles
11.
Korsholm L, Gal Z, Lin L, Quevedo O, Ahmad D, Dulina E, et al.
Nucleic Acids Res
. 2019 Jun;
47(15):8019-8035.
PMID: 31184714
The nucleolus is a nuclear sub-domain containing the most highly transcribed genes in the genome. Hundreds of human ribosomal RNA (rRNA) genes, located in the nucleolus, rely on constant maintenance....
12.
Larsen D, Hari F, Clapperton J, Gwerder M, Gutsche K, Altmeyer M, et al.
Nat Cell Biol
. 2014 Jul;
16(8):792-803.
PMID: 25064736
Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription...
13.
Luijsterburg M, Acs K, Ackermann L, Wiegant W, Bekker-Jensen S, Larsen D, et al.
EMBO J
. 2012 Apr;
31(11):2511-27.
PMID: 22531782
The ubiquitin ligases RNF8 and RNF168 orchestrate DNA damage signalling through the ubiquitylation of histone H2A and the recruitment of downstream repair factors. Here, we demonstrate that RNF8, but not...
14.
Jungmichel S, Clapperton J, Lloyd J, Hari F, Spycher C, Pavic L, et al.
Nucleic Acids Res
. 2012 Jan;
40(9):3913-28.
PMID: 22234878
Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat...