Doris Hoglinger
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Explore the profile of Doris Hoglinger including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
355
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Recent Articles
1.
Jamecna D, Hoglinger D
Methods Mol Biol
. 2024 Dec;
2888:249-258.
PMID: 39699736
Functionalized lipid analogs are a versatile tool for studying lipid localization, metabolism and interactions in cells. As a common follow-up research, in vitro experiments are utilized to confirm specific interactors...
2.
Nel L, Thaysen K, Jamecna D, Olesen E, Szomek M, Langer J, et al.
Life Sci Alliance
. 2024 Oct;
8(1).
PMID: 39455279
In eukaryotes, integration of sterols into the vacuolar/lysosomal membrane is critically dependent on the Niemann-Pick type C (NPC) system. The system consists of an integral membrane protein, called NCR1 in...
3.
Jamecna D, Hoglinger D
J Cell Sci
. 2024 Mar;
137(6).
PMID: 38488070
Sphingolipid dysregulation is involved in a range of rare and fatal diseases as well as common pathologies including cancer, infectious diseases or neurodegeneration. Gaining insights into how sphingolipids are involved...
4.
Hempelmann P, Lolicato F, Graziadei A, Brown R, Spiegel S, Rappsilber J, et al.
bioRxiv
. 2023 Oct;
PMID: 37790546
Sphingolipids are important structural components of membranes. Additionally, simple sphingolipids such as sphingosine are highly bioactive and participate in complex subcellular signaling. Sphingolipid deregulation is associated with many severe diseases...
5.
Bosteels V, Marechal S, De Nolf C, Rennen S, Maelfait J, Tavernier S, et al.
Sci Immunol
. 2023 May;
8(83):eadd3955.
PMID: 37172103
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways...
6.
Altuzar J, Notbohm J, Stein F, Haberkant P, Hempelmann P, Heybrock S, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2213886120.
PMID: 36893262
Lysosomes are catabolic organelles involved in macromolecular digestion, and their dysfunction is associated with pathologies ranging from lysosomal storage disorders to common neurodegenerative diseases, many of which have lipid accumulation...
7.
Griess K, Rieck M, Muller N, Karsai G, Hartwig S, Pelligra A, et al.
Nat Cell Biol
. 2022 Dec;
25(1):20-29.
PMID: 36543979
Impaired proinsulin-to-insulin processing in pancreatic β-cells is a key defective step in both type 1 diabetes and type 2 diabetes (T2D) (refs. ), but the mechanisms involved remain to be...
8.
Hartwig P, Hoglinger D
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34209164
For many years, the biology of glycosphingolipids was elucidated with the help of glucosylceramide synthase (GCS) inhibitors such as 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Additionally, PDMP gained interest because of its chemosensitizing effects....
9.
Schoop V, Martello A, Eden E, Hoglinger D
Biochim Biophys Acta Mol Cell Biol Lipids
. 2021 Jun;
1866(9):158989.
PMID: 34118431
Cholesterol is an essential component of eukaryotic cellular membranes. Information about its subcellular localization and transport pathways inside cells are key for the understanding and treatment of cholesterol-related diseases. In...
10.
Hoglinger D
Methods Mol Biol
. 2019 Feb;
1949:95-103.
PMID: 30790251
Investigations into lipid localization and transport are often hampered by a lack of methods and tools to faithfully visualize lipids in the context of living cells, since fluorescent modifications drastically...