Donna J Palmer
Overview
Explore the profile of Donna J Palmer including associated specialties, affiliations and a list of published articles.
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43
Citations
984
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Recent Articles
1.
Wacker B, Bi L, Liu L, Sorci-Thomas M, Ng P, Palmer D, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2023 Mar;
1868(5):159301.
PMID: 36858111
No abstract available.
2.
Tian J, Xu Z, Moitra R, Palmer D, Ng P, Byrnes A
PLoS Pathog
. 2022 Sep;
18(9):e1010859.
PMID: 36156097
The majority of adenovirus (Ad) vectors are based on human Ad type 5, which is a member of Ad species C. Species C also includes the closely-related types 1, 2,...
3.
Zhou J, Hamdan H, Yalamanchili H, Pang K, Pohodich A, Lopez J, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(4).
PMID: 35074918
MeCP2 is associated with Rett syndrome (RTT), duplication syndrome, and a number of conditions with isolated features of these diseases, including autism, intellectual disability, and motor dysfunction. MeCP2 is known...
4.
Jin Z, Kho J, Dawson B, Jiang M, Chen Y, Ali S, et al.
J Clin Invest
. 2020 Dec;
131(5).
PMID: 33373331
Previous studies have shown that nitric oxide (NO) supplements may prevent bone loss and fractures in preclinical models of estrogen deficiency. However, the mechanisms by which NO modulates bone anabolism...
5.
Palmer D, Turner D, Ng P
Mol Ther Methods Clin Dev
. 2020 Mar;
17:441-447.
PMID: 32154329
In this study, we developed a single helper-dependent adenovirus (HDAd) to deliver all of the components (donor DNA, CRISPR-associated protein 9 [Cas9], and guide RNA [gRNA]) needed to achieve high-efficiency...
6.
Hamdan H, Lim B, Torii T, Joshi A, Konning M, Smith C, et al.
Nat Commun
. 2020 Jan;
11(1):100.
PMID: 31900387
Axon initial segments (AISs) generate action potentials and regulate the polarized distribution of proteins, lipids, and organelles in neurons. While the mechanisms of AIS Na and K channel clustering are...
7.
Palmer D, Turner D, Ng P
Mol Ther Methods Clin Dev
. 2020 Jan;
15:285-293.
PMID: 31890728
We describe a strategy to achieve footprintless bi-allelic homology-directed repair (HDR) using helper-dependent adenoviruses (HDAds). This approach utilizes two HDAds to deliver the donor DNA. These two HDAds are identical...
8.
Palmer D, Turner D, Ng P
Mol Ther Methods Clin Dev
. 2019 May;
13:432-439.
PMID: 31080846
Prolonged expression of CRISPR/Cas9 raises concerns about off-target cleavage, cytotoxicity, and immune responses. To address these issues, we have developed a system to produce helper-dependent adenoviruses that express CRISPR/Cas9 to...
9.
Soria L, Nitzahn M, De Angelis A, Khoja S, Attanasio S, Annunziata P, et al.
J Inherit Metab Dis
. 2019 Feb;
42(6):1128-1135.
PMID: 30724386
The urea cycle and glutamine synthetase (GS) are the two main pathways for waste nitrogen removal and their deficiency results in hyperammonemia. Here, we investigated the efficacy of liver-specific GS...
10.
Khoja S, Nitzahn M, Hermann K, Truong B, Borzone R, Willis B, et al.
Mol Genet Metab
. 2018 May;
124(4):243-253.
PMID: 29801986
Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP. Bi-allelic mutations of the CPS1 gene result in a urea cycle...