Dongkyoo Park
Overview
Explore the profile of Dongkyoo Park including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
547
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0
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Recent Articles
11.
Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, et al.
Cancer Res
. 2017 Apr;
77(11):3001-3012.
PMID: 28381544
A rationale exists for pharmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy. Here, we report the refinement of the...
12.
Park D, Wang D, Chen G, Deng X
Bio Protoc
. 2017 Feb;
6(22).
PMID: 28184379
Patient-derived xenograft (PDX) models for cancer research have recently attracted considerable attention in both the academy and industry (Hidalgo ., 2014; Wilding and Bodmer, 2014). PDX models have been developed...
13.
Zhang J, Dai Q, Park D, Deng X
Genes (Basel)
. 2016 Aug;
7(8).
PMID: 27548226
The human cellular genome is under constant stress from extrinsic and intrinsic factors, which can lead to DNA damage and defective replication. In normal cells, DNA damage response (DDR) mediated...
14.
Nagaraju G, Rajitha B, Aliya S, Kotipatruni R, Madanraj A, Hammond A, et al.
Cytokine Growth Factor Rev
. 2016 Apr;
31:37-48.
PMID: 27079372
Adipose tissue is a highly vascularized endocrine organ, and its secretion profiles may vary with obesity. Adiponectin is secreted by adipocytes that make up adipose tissue. Worldwide, obesity has been...
15.
Deng J, Park D, Wang M, Nooka A, Deng Q, Matulis S, et al.
Oncotarget
. 2016 Apr;
7(19):27753-63.
PMID: 27049723
Multiple myeloma (MM) is a heterogeneous plasma cell malignancy and remains incurable. B-cell lymphoma-2 (BCL2) protein correlates with the survival and the drug resistance of myeloma cells. BH3 mimetics have...
16.
Zhang J, Park D, Shin D, Deng X
Acta Biochim Biophys Sin (Shanghai)
. 2015 Nov;
48(1):11-6.
PMID: 26578706
Oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) occur in 15%-30% of non-small cell lung cancer (NSCLC). However, despite decades of intensive research, there is still no direct...
17.
Han B, Park D, Li R, Xie M, Owonikoko T, Zhang G, et al.
Cancer Cell
. 2015 May;
27(6):852-63.
PMID: 26004684
The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified a small-molecule Bcl2-BH4 domain antagonist, BDA-366, that binds BH4 with high...
18.
Xie M, Park D, You S, Li R, Owonikoko T, Wang Y, et al.
Nucleic Acids Res
. 2015 Jan;
43(2):960-72.
PMID: 25567982
High-linear energy transfer ionizing radiation, derived from high charge (Z) and energy (E) (HZE) particles, induces clustered/complex DNA double-strand breaks (DSBs) that include small DNA fragments, which are not repaired...
19.
Xin M, Li R, Xie M, Park D, Owonikoko T, Sica G, et al.
Nat Commun
. 2014 Sep;
5:4935.
PMID: 25230299
Bax, a central death regulator, is required at the decisional stage of apoptosis. We recently identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic activity....
20.
Wang H, Wang X, Chen G, Zhang X, Tang X, Park D, et al.
J Biol Chem
. 2014 Sep;
289(44):30635-30644.
PMID: 25210033
High linear energy transfer (LET) radiation from space heavy charged particles or a heavier ion radiotherapy machine kills more cells than low LET radiation, mainly because high LET radiation-induced DNA...