Dong Sung An
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Explore the profile of Dong Sung An including associated specialties, affiliations and a list of published articles.
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45
Citations
2740
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Recent Articles
1.
Guo Q, Parikh K, Zhang J, Brinkley A, Chen G, Jakramonpreeya N, et al.
bioRxiv
. 2024 Nov;
PMID: 39605384
Hematopoietic stem/progenitor cell (HSPC)-based anti-HIV-1 gene therapy holds promise to provide life-long remission following a single treatment. Here we report a multi-pronged anti-HIV-1 HSPC-based gene therapy designed to defend against...
2.
Stevens C, Carmichael J, Watkinson R, Kowdle S, Reis R, Hamane K, et al.
J Virol
. 2024 Nov;
98(12):e0083224.
PMID: 39494910
Importance: Gene editing has the potential to be a powerful tool for the treatment of human diseases including HIV, β-thalassemias, and sickle cell disease. Recent advances have begun to overcome...
3.
Stevens C, Carmichael J, Watkinson R, Kowdle S, Reis R, Hamane K, et al.
bioRxiv
. 2024 May;
PMID: 38746439
The transformative potential of gene editing technologies hinges on the development of safe and effective delivery methods. In this study, we developed a temperature-sensitive and interferon-silent Sendai virus (ts SeV)...
4.
Guo Q, Zhang J, Parikh K, Brinkley A, Lin S, Zakarian C, et al.
Mol Ther
. 2023 Dec;
32(2):384-394.
PMID: 38087779
Hematopoietic stem/progenitor cell (HSPC)-based anti-HIV-1 gene therapy holds great promise to eradicate HIV-1 or to provide long-term remission through a continuous supply of anti-HIV-1 gene-modified cells without ongoing antiretroviral therapy....
5.
Shin A, An D, Bush N
Crit Care Nurse
. 2023 Nov;
43(6):34-46.
PMID: 38035620
Background: Patients critically ill with COVID-19 develop acute respiratory distress syndrome (ARDS) and may undergo prone positioning. Objective: To compare the effects of prone positioning on oxygenation, intensive care unit...
6.
Ladinsky M, Khamaikawin W, Jung Y, Lin S, Lam J, An D, et al.
Elife
. 2019 Oct;
8.
PMID: 31657719
Immune progenitor cells differentiate in bone marrow (BM) and then migrate to tissues. HIV-1 infects multiple BM cell types, but virus dissemination within BM has been poorly understood. We used...
7.
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer
Zhu Y, Smith D, Zhou Y, Li Y, Yu J, Lee D, et al.
Cell Stem Cell
. 2019 Sep;
25(4):542-557.e9.
PMID: 31495780
Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed...
8.
Srikanth S, Woo J, Wu B, El-Sherbiny Y, Leung J, Chupradit K, et al.
Nat Immunol
. 2019 Jan;
20(2):152-162.
PMID: 30643259
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor that is essential for the type I interferon response to DNA pathogens. Aberrant activation of STING is linked...
9.
Khamaikawin W, Shimizu S, Kamata M, Cortado R, Jung Y, Lam J, et al.
Mol Ther Methods Clin Dev
. 2018 Jan;
9:23-32.
PMID: 29322065
Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models. However, the clinical application...
10.
Smith D, Lin L, Moon H, Pham A, Wang X, Liu S, et al.
Stem Cells Dev
. 2016 Sep;
25(24):1863-1873.
PMID: 27608727
The humanized bone marrow-liver-thymus (BLT) mouse model harbors a nearly complete human immune system, therefore providing a powerful tool to study human immunology and immunotherapy. However, its application is greatly...