Donate Weghorn
Overview
Explore the profile of Donate Weghorn including associated specialties, affiliations and a list of published articles.
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12
Citations
330
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Recent Articles
1.
Angaji A, Owusu M, Velling C, Dick N, Weghorn D, Berg J
Elife
. 2024 Nov;
13.
PMID: 39587846
In growing cell populations such as tumours, mutations can serve as markers that allow tracking the past evolution from current samples. The genomic analyses of bulk samples and samples from...
2.
Faure A, Lehner B, Miro Pina V, Serrano Colome C, Weghorn D
PLoS Comput Biol
. 2024 May;
20(5):e1012132.
PMID: 38805561
Accurate models describing the relationship between genotype and phenotype are necessary in order to understand and predict how mutations to biological sequences affect the fitness and evolution of living organisms....
3.
Abad E, Sandoz J, Romero G, Zadra I, Urgel-Solas J, Borredat P, et al.
J Exp Clin Cancer Res
. 2024 Apr;
43(1):127.
PMID: 38685100
Background: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, like the...
4.
Benisty H, Hernandez-Alias X, Weber M, Anglada-Girotto M, Mantica F, Radusky L, et al.
Cell Syst
. 2023 Mar;
14(4):312-323.e3.
PMID: 36889307
Codon usage influences gene expression distinctly depending on the cell context. Yet, the importance of codon bias in the simultaneous turnover of specific groups of protein-coding genes remains to be...
5.
Rodriguez-Galindo M, Casillas S, Weghorn D, Barbadilla A
Nat Commun
. 2020 Jul;
11(1):3304.
PMID: 32620809
A main assumption of molecular population genetics is that genomic mutation rate does not depend on sequence function. Challenging this assumption, a recent study has found a reduction in the...
6.
Dietlein F, Weghorn D, Taylor-Weiner A, Richters A, Reardon B, Liu D, et al.
Nat Genet
. 2020 Feb;
52(2):208-218.
PMID: 32015527
Cancer genomes contain large numbers of somatic mutations but few of these mutations drive tumor development. Current approaches either identify driver genes on the basis of mutational recurrence or approximate...
7.
Weghorn D, Balick D, Cassa C, Kosmicki J, Daly M, Beier D, et al.
Mol Biol Evol
. 2019 Apr;
36(8):1701-1710.
PMID: 31004148
The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans...
8.
Cassa C, Weghorn D, Balick D, Jordan D, Nusinow D, Samocha K, et al.
Nat Genet
. 2018 Nov;
51(1):3-4.
PMID: 30478437
No abstract available.
9.
Weghorn D, Sunyaev S
Nat Genet
. 2017 Nov;
49(12):1785-1788.
PMID: 29106416
Cancer genomics efforts have identified genes and regulatory elements driving cancer development and neoplastic progression. From a microevolution standpoint, these are subject to positive selection. Although elusive in current studies,...
10.
D Antonio M, Weghorn D, D Antonio-Chronowska A, Coulet F, Olson K, DeBoever C, et al.
Nat Commun
. 2017 Sep;
8(1):436.
PMID: 28874753
Efforts to identify driver mutations in cancer have largely focused on genes, whereas non-coding sequences remain relatively unexplored. Here we develop a statistical method based on characteristics known to influence...