Donald Henderson
Overview
Explore the profile of Donald Henderson including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1172
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Recent Articles
1.
Xu Y, Yang W, Hu B, Yang S, Henderson D
Acta Otolaryngol
. 2017 Jan;
137(6):572-580.
PMID: 28093932
Conclusion: p53 and Bcl-2 (B-cell lymphoma 2) are involved in the process of sensory cell degeneration in aging cochleae. Objective: To determine molecular players in age-related hair cell degeneration, this...
2.
Fetoni A, Bielefeld E, Paludetti G, Nicotera T, Henderson D
Neurosci Res
. 2014 Jan;
81-82:30-7.
PMID: 24472721
Exposure to high-level noise leads to oxidative stress and triggers apoptosis of the hair cells. This study examined whether p53, a tumor suppressor protein, is activated in the cochlea following...
3.
Wack D, Cox J, Schirda C, Magnano C, Sussman J, Henderson D, et al.
PLoS One
. 2012 Aug;
7(7):e41263.
PMID: 22848453
Introduction: Masking level differences (MLDs) are differences in the hearing threshold for the detection of a signal presented in a noise background, where either the phase of the signal or...
4.
Bielefeld E, Tanaka C, Chen G, Coling D, Li M, Henderson D, et al.
Anticancer Drugs
. 2012 Jul;
24(1):43-51.
PMID: 22828384
Ototoxicity remains a major dose-limiting side effect of cisplatin. The current studies were carried out to evaluate the effectiveness of a novel Src-protein tyrosine kinase inhibitor in protecting the ear...
5.
Tanaka C, Coling D, Manohar S, Chen G, Hu B, Salvi R, et al.
Neurobiol Aging
. 2012 Feb;
33(8):1842.e1-14.
PMID: 22300951
The biological mechanisms that give rise to age-related hearing loss (ARHL) are still poorly understood. However, there is growing recognition that oxidative stress may be an important factor. To address...
6.
Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors
Bielefeld E, Hangauer D, Henderson D
Neurosci Res
. 2011 Aug;
71(4):348-54.
PMID: 21840347
Apoptosis is a significant mechanism of cochlear hair cell loss from noise. Molecules that inhibit apoptotic intracellular signaling reduce cochlear damage and hearing loss from noise. The current study is...
7.
Bielefeld E, Wantuck R, Henderson D
Noise Health
. 2011 Jul;
13(53):292-8.
PMID: 21768733
Both the antioxidant, N-l-acetyl cysteine (NAC), and the Src inhibitor, KX1-004, have been used to protect the cochlea from hazardous noise. In order to extend our previous work on KX1-004...
8.
Yang W, Hu B, Chen G, Bielefeld E, Henderson D
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
. 2011 May;
25(4):176-9.
PMID: 21563467
Objective: To observe the effects of N-acetyl-L-cysteine (L-NAC) protect hair cells in the rat cochlea from injury of exposure to styrene. Method: Seventeen adult Long Evans rats were used in...
9.
Yang W, Hu B, Sun J, Zhai S, Henderson D
Chin Med J (Engl)
. 2010 Sep;
123(13):1633-8.
PMID: 20819620
Background: Our previous studies have shown that both apoptosis and necrosis are involved in hair cell (HC) pathogenesis in aging cochleae. To better understand the biological mechanisms responsible for the...
10.