Domitilla Del Vecchio
Overview
Explore the profile of Domitilla Del Vecchio including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
1083
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Recent Articles
1.
Palacios S, Collins J, Del Vecchio D
Curr Opin Biotechnol
. 2025 Jan;
92:103263.
PMID: 39874719
Synthetic biology leverages engineering principles to program biology with new functions for applications in medicine, energy, food, and the environment. A central aspect of synthetic biology is the creation of...
2.
Bruno S, Schlaeger T, Del Vecchio D
NPJ Syst Biol Appl
. 2024 Jan;
10(1):3.
PMID: 38184707
Experimental studies have shown that chromatin modifiers have a critical effect on cellular reprogramming, i.e., the conversion of differentiated cells to pluripotent stem cells. Here, we develop a model of...
3.
Ilia K, Shakiba N, Bingham T, Jones R, Kaminski M, Aravera E, et al.
Sci Adv
. 2023 Nov;
9(48):eadg8495.
PMID: 38019912
Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming...
4.
Jones R, Qian Y, Ilia K, Wang B, Laub M, Del Vecchio D, et al.
Nat Commun
. 2023 Aug;
14(1):4775.
PMID: 37553375
No abstract available.
5.
Campos F, Bruno S, Fu Y, Del Vecchio D, Williams R
Bull Math Biol
. 2023 Mar;
85(5):39.
PMID: 37000280
Continuous-time Markov chains are frequently used as stochastic models for chemical reaction networks, especially in the growing field of systems biology. A fundamental problem for these Stochastic Chemical Reaction Networks...
6.
Bruno S, Del Vecchio D
bioRxiv
. 2023 Mar;
PMID: 36909486
In the last decade, several experimental studies have shown how chromatin modifications (histone modifications and DNA methylation) and their effect on DNA compaction have a critical effect on cellular reprogramming,...
7.
Kwon U, Huang H, Chavez J, Beabout K, Harbaugh S, Del Vecchio D
Nucleic Acids Res
. 2023 Feb;
51(6):2963-2973.
PMID: 36840726
A ratiometric response gives an output that is proportional to the ratio between the magnitudes of two inputs. Ratio computation has been observed in nature and is also needed in...
8.
Ilia K, Shakiba N, Bingham T, Jones R, Kaminski M, Aravera E, et al.
bioRxiv
. 2023 Feb;
PMID: 36747813
Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless, the impact of TF dynamics on reprogramming...
9.
Barajas C, Huang H, Gibson J, Sandoval L, Del Vecchio D
Nat Commun
. 2022 Nov;
13(1):7054.
PMID: 36396941
Heterologous gene activation causes non-physiological burden on cellular resources that cells are unable to adjust to. Here, we introduce a feedforward controller that actuates growth rate upon activation of a...
10.
Barajas C, Del Vecchio D
Curr Opin Biotechnol
. 2022 Nov;
78:102837.
PMID: 36343564
Natural biological systems display complex regulation and synthetic biomolecular systems have been used to understand their natural counterparts and to parse sophisticated regulations into core design principles. At the same...