Dominique Pessayre
Overview
Explore the profile of Dominique Pessayre including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
48
Citations
2510
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Corsini A, Ganey P, Ju C, Kaplowitz N, Pessayre D, Roth R, et al.
Drug Saf
. 2012 Nov;
35(12):1099-117.
PMID: 23137150
Current key challenges and controversies encountered in the identification of potentially hepatotoxic drugs and the assessment of drug-induced liver injury (DILI) are covered in this article. There is substantial debate...
2.
Nahon P, Sutton A, Rufat P, Charnaux N, Mansouri A, Moreau R, et al.
J Hepatol
. 2011 Sep;
56(2):426-32.
PMID: 21907168
Background & Aims: Genetic dimorphisms modulate the activities of several pro- or antioxidant enzymes, including myeloperoxidase (MPO), catalase (CAT), manganese superoxide dismutase (SOD2), and glutathione peroxidase 1 (GPx1). We assessed...
3.
Pessayre D, Fromenty B, Berson A, Robin M, Letteron P, Moreau R, et al.
Drug Metab Rev
. 2011 Sep;
44(1):34-87.
PMID: 21892896
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events cause mitochondrial membrane disruption. Genetic...
4.
Choumar A, Tarhuni A, Letteron P, Reyl-Desmars F, Dauhoo N, Damasse J, et al.
Antioxid Redox Signal
. 2011 Jul;
15(11):2837-54.
PMID: 21767162
Hepatic energy depletion has been described in severe sepsis, and lipopolysaccharide (LPS) has been shown to cause mitochondrial DNA (mtDNA) damage. To clarify the mechanisms of LPS-induced mtDNA damage and...
5.
Mansouri A, Tarhuni A, Larosche I, Reyl-Desmars F, Demeilliers C, Degoul F, et al.
Dig Dis
. 2011 Apr;
28(6):756-75.
PMID: 21525761
Both acute and chronic alcohol consumption increase reactive oxygen species (ROS) formation and lipid peroxidation, whose products damage hepatic mitochondrial DNA (mtDNA). To test whether manganese superoxide dismutase (MnSOD) overexpression...
6.
Nahon P, Sutton A, Pessayre D, Rufat P, Charnaux N, Trinchet J, et al.
Antioxid Redox Signal
. 2010 Aug;
15(1):31-8.
PMID: 20673159
Iron-induced oxidative stress promotes hepatic injury in hereditary hemochromatosis, which can be influenced by genetic traits affecting antioxidant enzymes. We assessed the influence of Ala16Val-superoxide dismutase 2, Pro198Leu-glutathione peroxidase 1,...
7.
Pessayre D, Mansouri A, Berson A, Fromenty B
Handb Exp Pharmacol
. 2009 Dec;
(196):311-65.
PMID: 20020267
Mitochondrial dysfunction is a major mechanism of liver injury. A parent drug or its reactive metabolite can trigger outer mitochondrial membrane permeabilization or rupture due to mitochondrial permeability transition. The...
8.
Larosche I, Letteron P, Berson A, Fromenty B, Huang T, Moreau R, et al.
J Pharmacol Exp Ther
. 2009 Dec;
332(3):886-97.
PMID: 20016022
Alcohol consumption increases reactive oxygen species (ROS) formation, which can damage mitochondrial DNA (mtDNA) and alter mitochondrial function. To test whether manganese superoxide dismutase (MnSOD) modulates acute alcohol-induced mitochondrial alterations,...
9.
Nahon P, Sutton A, Rufat P, Ziol M, Akouche H, Laguillier C, et al.
Hepatology
. 2009 Sep;
50(5):1484-93.
PMID: 19731237
Unlabelled: Alcohol increases reactive oxygen species (ROS) formation in hepatocyte mitochondria and by reduced nicotinamide adenine dinucleotide phosphate oxidases and myeloperoxidase (MPO) in Kupffer cells and liver-infiltrating neutrophils. Manganese superoxide...
10.
Larosche I, Choumar A, Fromenty B, Letteron P, Abbey-Toby A, Van Remmen H, et al.
Toxicol Appl Pharmacol
. 2008 Dec;
234(3):326-38.
PMID: 19063909
Alcohol consumption increases reactive oxygen species formation and lipid peroxidation, whose products can damage mitochondrial DNA (mtDNA) and alter mitochondrial function. A possible role of manganese superoxide dismutase (MnSOD) on...