Dominique de Kleijn
Overview
Explore the profile of Dominique de Kleijn including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
2248
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0
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Recent Articles
1.
Kalailingam P, Ngan S, Iyappan R, Nehchiri A, Mohd-Kahliab K, Lee B, et al.
Aging Cell
. 2025 Jan;
:e14425.
PMID: 39757428
Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable,...
2.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2023 May;
618(7965):E19-E20.
PMID: 37237109
No abstract available.
3.
Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, et al.
Genome Biol
. 2022 Dec;
23(1):268.
PMID: 36575460
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of...
4.
Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, et al.
Am J Hum Genet
. 2022 Aug;
109(8):1366-1387.
PMID: 35931049
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from...
5.
Doug Deen A, van Beusekom H, Pfeiffer T, Stam M, de Kleijn D, Wentzel J, et al.
Biomed Opt Express
. 2022 Jul;
13(6):3503.
PMID: 35781974
[This corrects the article on p. 1430 in vol. 13, PMID: 35414978.].
6.
Doug Deen A, van Beusekom H, Pfeiffer T, Stam M, de Kleijn D, Wentzel J, et al.
Biomed Opt Express
. 2022 Apr;
13(3):1430-1446.
PMID: 35414978
Optical imaging techniques that provide free space, label free imaging are powerful tools in obtaining structural and biochemical information in biological samples. To date, most of the optical imaging technologies...
7.
Nurmohamed N, Belo Pereira J, Hoogeveen R, Kroon J, Kraaijenhof J, Waissi F, et al.
Eur Heart J
. 2022 Feb;
43(16):1569-1577.
PMID: 35139537
Aims: Current risk scores do not accurately identify patients at highest risk of recurrent atherosclerotic cardiovascular disease (ASCVD) in need of more intensive therapeutic interventions. Advances in high-throughput plasma proteomics,...
8.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2021 Dec;
600(7890):675-679.
PMID: 34887591
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use. Despite advances in prevention and treatment, in...
9.
Gimona M, Brizzi M, Choo A, Dominici M, Davidson S, Grillari J, et al.
Cytotherapy
. 2021 May;
23(5):373-380.
PMID: 33934807
Mesenchymal stromal/stem cells (MSCs) have been widely tested against many diseases, with more than 1000 registered clinical trials worldwide. Despite many setbacks, MSCs have been approved for the treatment of...
10.
Fiolet A, Silvis M, Opstal T, Bax W, van der Horst F, Mosterd A, et al.
PLoS One
. 2020 Sep;
15(8):e0237665.
PMID: 32866166
Aims: Inflammation plays a pivotal role in atherothrombosis. Colchicine is an anti-inflammatory drug that may attenuate this process. Cardiovascular protective effects of anti-inflammatory drugs, however, seem to be limited to...