Dominik Pistorius
Overview
Explore the profile of Dominik Pistorius including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
307
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Recent Articles
1.
Helf M, Buntin K, Klancar A, Rust M, Petersen F, Pistorius D, et al.
Nat Prod Rep
. 2024 Aug;
41(12):1824-1834.
PMID: 39129507
Covering 1986 to presentNatural product drug discovery at Novartis has a long and successful history of delivering life saving medicines to millions of patients. In this viewpoint, we are presenting...
2.
Pistorius D, Richard E, Buntin K, Dresen K, Wollbrett S, Weber E, et al.
Chembiochem
. 2024 Jul;
25(21):e202400491.
PMID: 39076125
The natural product FR900359 (FR) has generated significant attention lately, due to its characteristics as potent and selective inhibitor of G mediated signal transduction of associated G protein-coupled receptors (GPCRs)....
3.
Pistorius D, Buntin K, Richard E, Rust M, Bouquet C, Wollbrett S, et al.
J Nat Prod
. 2023 Feb;
86(2):246-255.
PMID: 36745695
Microbial secondary metabolites continue to provide a valuable source of both chemical matter and inspiration for drug discovery in a broad range of therapeutic areas. Beyond this, the corresponding microorganisms...
4.
Pistorius D, Buntin K, Weber E, Richard E, Bouquet C, Wollbrett S, et al.
Chemistry
. 2021 Dec;
28(8):e202103888.
PMID: 34878202
Access to the cyclic depsipeptide FR900359 (FR), a selective G protein inhibitor of high pharmacological interest and a potential lead molecule for targeted therapy of cancers with oncogenic GNAQ or...
5.
Buntin K, Ertl P, Hoepfner D, Krastel P, Oakeley E, Pistorius D, et al.
Chimia (Aarau)
. 2021 Sep;
75(7-8):620-633.
PMID: 34523403
Natural Products (NPs) are molecular' special equipment ' that impart survival benefits on their producers in nature. Due to their evolved functions to modulate biology these privileged metabolites are substantially...
6.
Fu Y, Estoppey D, Roggo S, Pistorius D, Fuchs F, Studer C, et al.
Nat Commun
. 2020 Aug;
11(1):3913.
PMID: 32737318
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Fu Y, Estoppey D, Roggo S, Pistorius D, Fuchs F, Studer C, et al.
Nat Commun
. 2020 Jul;
11(1):3387.
PMID: 32636417
Biosynthesis of glycosylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essential for the integrity of the fungal cell wall. Here, we use a reporter gene-based...
8.
Tranter D, Filipuzzi I, Lochmann T, Knapp B, Kellosalo J, Estoppey D, et al.
J Nat Prod
. 2020 Mar;
83(4):965-971.
PMID: 32182062
Kendomycin is a small-molecule natural product that has gained significant attention due to reported cytotoxicity against pathogenic bacteria and fungi as well as a number of cancer cell lines. Despite...
9.
Mrak P, Krastel P, Pivk Lukancic P, Tao J, Pistorius D, Moore C
J Biol Chem
. 2018 Oct;
293(52):19982-19995.
PMID: 30327433
Actinobacteria possess a great wealth of pathways for production of bioactive compounds. Following advances in genome mining, dozens of natural product (NP) gene clusters are routinely found in each actinobacterial...
10.
Jackson D, Tu S, Nguyen M, Barajas J, Schaub A, Krug D, et al.
ACS Chem Biol
. 2015 Oct;
11(1):95-103.
PMID: 26473393
The incorporation of nonacetate starter units during type II polyketide biosynthesis helps diversify natural products. Currently, there are few enzymatic strategies for the incorporation of nonacetate starter units in type...