Dominik Hoelper
Overview
Explore the profile of Dominik Hoelper including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
532
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0
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Recent Articles
1.
Jain S, Rashoff A, Krabbenhoft S, Hoelper D, Do T, Gibson T, et al.
Mol Cell
. 2020 Oct;
80(4):726-735.e7.
PMID: 33049227
Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and...
2.
Strekalova E, Malin D, Weisenhorn E, Russell J, Hoelper D, Jain A, et al.
Breast Cancer Res Treat
. 2019 Feb;
175(1):39-50.
PMID: 30712196
Purpose: Many transformed cells and embryonic stem cells are dependent on the biosynthesis of the universal methyl-donor S-adenosylmethionine (SAM) from methionine by the enzyme MAT2A to maintain their epigenome. We...
3.
Hoelper D, Huang H, Jain A, Patel D, Lewis P
Nat Commun
. 2017 Nov;
8(1):1193.
PMID: 29084956
The ATRX-DAXX histone chaperone complex incorporates the histone variant H3.3 at heterochromatic regions in a replication-independent manner. Here, we present a high-resolution x-ray crystal structure of an interaction surface between...
4.
Jayaram H, Hoelper D, Jain S, Cantone N, Lundgren S, Poy F, et al.
Proc Natl Acad Sci U S A
. 2016 May;
113(22):6182-7.
PMID: 27185940
Lysine to methionine (K-to-M) mutations in genes encoding histone H3 are thought to drive a subset of pediatric brain and bone cancers. These high-frequency K-to-M mutations occur at sites of...
5.
Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, et al.
Science
. 2016 May;
352(6287):844-9.
PMID: 27174990
Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36-to-methionine (H3K36M)...
6.
Gaebler A, Milan R, Straub L, Hoelper D, Kuerschner L, Thiele C
J Lipid Res
. 2013 May;
54(8):2282-2290.
PMID: 23709689
Click chemistry is evolving as a powerful tool in biological applications because it allows the sensitive and specific detection of compounds with alkyne or azido groups. Here we describe the...
7.
Thiele C, Papan C, Hoelper D, Kusserow K, Gaebler A, Schoene M, et al.
ACS Chem Biol
. 2012 Sep;
7(12):2004-11.
PMID: 22999348
Fatty acids are abundant constituents of all biological systems, and their metabolism is important for normal function at all levels of an organism. Aberrations in fatty acid metabolism are associated...