Dominic A Scudiero
Overview
Explore the profile of Dominic A Scudiero including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
1049
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0
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Recent Articles
1.
Mertins S, Scudiero D, Hollingshead M, Divelbiss Jr R, Alley M, Monks A, et al.
PLoS One
. 2013 Feb;
8(2):e57099.
PMID: 23437320
Background: Cancer stem cells (CSC) are thought to be responsible for tumor maintenance and heterogeneity. Bona fide CSC purified from tumor biopsies are limited in supply and this hampers study...
2.
Saini V, Hose C, Monks A, Nagashima K, Han B, Newton D, et al.
PLoS One
. 2012 Aug;
7(8):e41401.
PMID: 22870217
Recently, there has been renewed interest in the role of tumor stem cells (TSCs) in tumorigenesis, chemoresistance, and relapse of malignant tumors including osteosarcoma. The potential exists to improve osteosarcoma...
3.
Klausmeyer P, McCloud T, Scudiero D, Currens M, Cardellina Ii J, Shoemaker R
Bioorg Med Chem
. 2012 Jul;
20(15):4646-52.
PMID: 22766217
A high throughput in vitro screen has been developed to identify substances that induce expression of C/EBPα in tumor cells. An extract of the fruit of Gyrocarpus jacquinii showed induction...
4.
Gussio R, Currens M, Scudiero D, Smith J, Lannigan D, Shoemaker R, et al.
J Chem Pharm Res
. 2011 Oct;
2(5):587-598.
PMID: 21593990
Due to its overexpression and activation in human cancer cells and tissues, an emerging molecular target in cancer therapeutics is p90 ribosomal s6 kinase 2 (RSK2). While a growing number...
5.
Dulyaninova N, Hite K, Zencheck W, Scudiero D, Almo S, Shoemaker R, et al.
Biochemistry
. 2011 Jul;
50(33):7218-27.
PMID: 21749055
Overexpression of S100A4, a member of the S100 family of Ca(2+)-binding proteins, is associated with a number of human pathologies, including fibrosis, inflammatory disorders, and metastatic disease. The identification of...
6.
Stuelten C, Mertins S, Busch J, Gowens M, Scudiero D, Burkett M, et al.
Stem Cells
. 2010 Feb;
28(4):649-60.
PMID: 20178109
Tumor stem cells or cancer initiating cells (CICs) are single tumor cells that can regenerate a tumor or a metastasis. The identification and isolation of CICs remain challenging, and a...
7.
Klausmeyer P, Zhou Q, Scudiero D, Uranchimeg B, Melillo G, Cardellina J, et al.
J Nat Prod
. 2009 May;
72(5):805-12.
PMID: 19405508
Cytotoxicity-guided fractionation of an organic solvent extract of the plant Crossosoma bigelovii led to the discovery of a new strophanthidin glycoside (1) and two new 2-methylchromone glycosides (2 and 3)....
8.
Meragelman T, Scudiero D, Davis R, Staudt L, McCloud T, Cardellina 2nd J, et al.
J Nat Prod
. 2008 Dec;
72(3):336-9.
PMID: 19093800
The nuclear factor-kappaB (NF-kappaB) signaling pathway is constitutively active in many types of cancers and is a potential therapeutic target. Using a cell-based assay for stability of inhibitor of kappa...
9.
Klausmeyer P, McCloud T, Uranchimeg B, Melillo G, Scudiero D, Cardellina 2nd J, et al.
Planta Med
. 2008 Feb;
74(3):258-63.
PMID: 18302092
A crude organic solvent extract of Alangium cf. longiflorum exhibited potent inhibition of hypoxia-induced HIF-1 transcriptional activity in human U251 glioma cells. Dereplication and bioactivity-guided fractionation, including Sephadex LH-20 and...
10.
Amundson S, Do K, Vinikoor L, Lee R, Koch-Paiz C, Ahn J, et al.
Cancer Res
. 2008 Jan;
68(2):415-24.
PMID: 18199535
The 60 cell lines of the National Cancer Institute Anticancer Drug Screen (NCI-60) constitute the most extensively characterized in vitro cancer cell model. They have been tested for sensitivity to...