Dmitry Borkin
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Explore the profile of Dmitry Borkin including associated specialties, affiliations and a list of published articles.
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14
Citations
735
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Recent Articles
1.
Rogawski D, Deng J, Li H, Miao H, Borkin D, Purohit T, et al.
Nat Commun
. 2021 May;
12(1):2792.
PMID: 33990599
ASH1L histone methyltransferase plays a crucial role in the pathogenesis of different diseases, including acute leukemia. While ASH1L represents an attractive drug target, developing ASH1L inhibitors is challenging, as the...
2.
Borkin D, Klossowski S, Pollock J, Miao H, Linhares B, Kempinska K, et al.
J Med Chem
. 2018 May;
61(11):4832-4850.
PMID: 29738674
The protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1) plays an important role in development of acute leukemia with translocations of the MLL1 gene and in solid tumors. Here,...
3.
Smith S, Jammalamadaka V, Borkin D, Zhu J, Degrado S, Lu J, et al.
ACS Med Chem Lett
. 2018 Jan;
9(1):56-60.
PMID: 29348812
Antibody-drug conjugates (ADCs) represent an important class of emerging cancer therapeutics. Recent ADC development efforts highlighted the use of pyrrolobenzodiazepine (PBD) dimer payload for the treatment of several cancers. We...
4.
Kempinska K, Malik B, Borkin D, Klossowski S, Shukla S, Miao H, et al.
Mol Cancer Ther
. 2017 Nov;
17(1):26-38.
PMID: 29142068
Hepatocellular carcinoma (HCC) accounts for approximately 85% of malignant liver tumors and results in 600,000 deaths each year, emphasizing the need for new therapies. Upregulation of menin was reported in...
5.
Seaman S, Zhu Z, Saha S, Zhang X, Yang M, Hilton M, et al.
Cancer Cell
. 2017 Apr;
31(4):501-515.e8.
PMID: 28399408
Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal...
6.
Svoboda L, Bailey N, Van Noord R, Krook M, Harris A, Cramer C, et al.
Oncotarget
. 2016 Nov;
8(1):458-471.
PMID: 27888797
Developmental transcription programs are epigenetically regulated by the competing actions of polycomb and trithorax (TrxG) protein complexes, which repress and activate genes, respectively. Ewing sarcoma is a developmental tumor that...
7.
Borkin D, Pollock J, Kempinska K, Purohit T, Li X, Wen B, et al.
J Med Chem
. 2016 Jan;
59(3):892-913.
PMID: 26744767
Development of potent small molecule inhibitors of protein-protein interactions with optimized druglike properties represents a challenging task in lead optimization process. Here, we report synthesis and structure-based optimization of new...
8.
Pollock J, Borkin D, Lund G, Purohit T, Dyguda-Kazimierowicz E, Grembecka J, et al.
J Med Chem
. 2015 Aug;
58(18):7465-74.
PMID: 26288158
Multipolar interactions involving fluorine and the protein backbone have been frequently observed in protein-ligand complexes. Such fluorine-backbone interactions may substantially contribute to the high affinity of small molecule inhibitors. Here...
9.
Malik R, Khan A, Asangani I, Cieslik M, Prensner J, Wang X, et al.
Nat Med
. 2015 Mar;
21(4):344-52.
PMID: 25822367
Resistance to androgen deprivation therapies and increased androgen receptor (AR) activity are major drivers of castration-resistant prostate cancer (CRPC). Although prior work has focused on targeting AR directly, co-activators of...
10.
Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, et al.
Cancer Cell
. 2015 Mar;
27(4):589-602.
PMID: 25817203
Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion proteins is dependent on their interaction with menin, providing...