Dmitrii V Pyshnyi
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Explore the profile of Dmitrii V Pyshnyi including associated specialties, affiliations and a list of published articles.
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56
Citations
393
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Recent Articles
1.
Nekrasov M, Pyshnyi D, Kupryushkin M
Med Chem
. 2025 Mar;
21(3):229-238.
PMID: 40070143
Introduction: Nowadays, use of phosphate modifications in oligonucleotide backbone has become a common approach for imbuing its structure with the desired beneficial properties. The recent advances in successful application of...
2.
Chubarov A, Baranovskaya E, Oscorbin I, Yushin I, Filipenko M, Pyshnyi D, et al.
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203788
Detection of the Kirsten rat sarcoma gene () mutational status is an important factor for the treatment of various malignancies. The most common -activating mutations are caused by single-nucleotide mutations,...
3.
Kanarskaya M, Pyshnyi D, Lomzov A
Molecules
. 2024 Jan;
29(1).
PMID: 38202593
New tool development for various nucleic acid applications is an essential task in RNA nanotechnology. Here, we determined the ability of self-limited complex formation by a pair of oligoribonucleotides carrying...
4.
Pavlova A, Ilyushchenko V, Kupryushkin M, Zharkov T, Dyudeeva E, Bauer I, et al.
Biochemistry (Mosc)
. 2023 Sep;
88(8):1165-1180.
PMID: 37758315
Serum albumin is currently in the focus of biomedical research as a promising platform for the creation of multicomponent self-assembling systems due to the presence of several sites with high...
5.
Chubarov A, Oscorbin I, Novikova L, Filipenko M, Lomzov A, Pyshnyi D
Diagnostics (Basel)
. 2023 Jan;
13(2).
PMID: 36673060
Phosphoryl guanidine (PG) is the novel uncharged modification of internucleotide phosphates of oligonucleotides. Incorporating PG modification into PCR primers leads to increased discrimination between wild-type and mutated DNA, providing extraordinary...
6.
Vasilyeva S, Baranovskaya E, Dyudeeva E, Lomzov A, Pyshnyi D
ACS Omega
. 2023 Jan;
8(1):1556-1566.
PMID: 36643477
In this work, we present new oligonucleotide derivatives containing inter-nucleotide -benzimidazole, -benzoxazole, -benzothiazole, and 1,3-dimethyl--benzimidazole (benzoazoles) phosphoramide groups. These modifications were introduced via the Staudinger reaction with appropriate azides during...
7.
Vasilyeva S, Kuznetsova A, Baranovskaya E, Kuznetsov N, Lomzov A, Pyshnyi D
Bioorg Chem
. 2022 Jul;
127:105987.
PMID: 35777231
Efficient protocols were developed for the synthesis of a new compounds - nucleoside 5'-α-iminophosphates using the Staudinger reaction. These substances are alpha-phosphate mimetic nucleotide in which an oxygen atom is...
8.
Zamoskovtseva A, Golyshev V, Kizilova V, Shevelev G, Pyshnyi D, Lomzov A
RSC Adv
. 2022 Apr;
12(11):6416-6431.
PMID: 35424594
The development of approaches to the design of two- and three-dimensional self-assembled DNA-based nanostructures with a controlled shape and size is an essential task for applied nanotechnology, therapy, biosensing, and...
9.
Kupryushkin M, Filatov A, Mironova N, Patutina O, Chernikov I, Chernolovskaya E, et al.
Mol Ther Nucleic Acids
. 2022 Jan;
27:211-226.
PMID: 34976439
Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3' and 5' ends were prepared via the Staudinger chemistry, which...
10.
Epanchintseva A, Poletaeva J, Dovydenko I, Chelobanov B, Pyshnyi D, Ryabchikova E, et al.
Nanomaterials (Basel)
. 2021 Nov;
11(11).
PMID: 34835540
There is an urgent need to develop systems for nucleic acid delivery, especially for the creation of effective therapeutics against various diseases. We have previously shown the feasibility of efficient...