Divya Muthiah
Overview
Explore the profile of Divya Muthiah including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
30
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0
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Recent Articles
1.
Muthiah D, Chan M, Low Y, Ramasamy S, Amin Z, Chan-Ng P, et al.
Front Pediatr
. 2024 Jul;
12:1382133.
PMID: 39026941
Introduction: The aim of the study was to summarize and update clinical features and outcomes of multisystem inflammatory syndrome in neonates (MIS-N). Methods: A systematic literature search was conducted of...
2.
Yong C, Devine S, Abel A, Tomlins S, Muthiah D, Gao X, et al.
ChemMedChem
. 2021 Jun;
16(18):2882-2894.
PMID: 34159741
Since the revelation of noscapine's weak anti-mitotic activity, extensive research has been conducted over the past two decades, with the goal of discovering noscapine derivatives with improved potency. To date,...
3.
Muthiah D, Henshaw G, DeBono A, Capuano B, Scammells P, Callaghan R
Drug Metab Dispos
. 2018 Nov;
47(2):164-172.
PMID: 30478158
The antitussive agent noscapine has been shown to inhibit the proliferation of cancer cells by disruption of tubulin dynamic. However, the efficacy of several anticancer drugs that inhibit tublin dynamics...
4.
Devine S, Yong C, Amenuvegbe D, Aurelio L, Muthiah D, Pouton C, et al.
J Med Chem
. 2018 Aug;
61(18):8444-8456.
PMID: 30156410
A series of 5-substituted tetrahydroisoquinolines was synthesized via a 10-step linear synthesis to assess whether replacement of noscapine's southern isobenzofuranone with other moieties resulted in retained cytotoxic activity. One such...
5.
Muthiah D, Callaghan R
Eur J Pharmacol
. 2017 Sep;
815:127-137.
PMID: 28912036
ZSTK474 is a potent phosphoinositide 3-kinase (PI3K) inhibitor that reduces cell proliferation via G-arrest. However, there is little information on the susceptibility of this anticancer drug to resistance conferred by...
6.
DeBono A, Mistry S, Xie J, Muthiah D, Phillips J, Ventura S, et al.
ChemMedChem
. 2013 Dec;
9(2):399-410.
PMID: 24339417
Noscapine, a phthalideisoquinoline alkaloid derived from Papaver somniferum, is a well-known antitussive drug that has a relatively safe in vitro toxicity profile. Noscapine is also known to possess weak anticancer...